2-Bromo-4-formyl-6-methoxyphenyl acetate

Base Information

• Chemical Name: 2-Bromo-4-formyl-6-methoxyphenyl acetate
• CAS No.: 308088-29-1
• Molecular Formula: C10H9 Br O4
• Molecular Weight: 273.08
• Hs Code.: 2915390090
• European Community (EC) Number: 878-382-0
• DSSTox Substance ID: DTXSID10366381
• Wikidata: Q82151567
• Mol file: 308088-29-1.mol

Synonyms:2-bromo-4-formyl-6-methoxyphenyl acetate;308088-29-1;(2-bromo-4-formyl-6-methoxyphenyl) acetate;2-BROMO-4-FORMYL-6-METHOXYPHENYLACETATE;SCHEMBL4324647;DTXSID10366381;SXSITNPVULYEFB-UHFFFAOYSA-N;BBL036359;MFCD02090077;STK336089;AKOS000305239;VS-13435;B5230;CS-0217895;FT-0709674;EN300-92278;D95285;Benzaldehyde, 4-(acetyloxy)-3-bromo-5-methoxy-;SR-01000262038;SR-01000262038-1;Z57887714

Chemical Property of 2-Bromo-4-formyl-6-methoxyphenyl acetate

Chemical Property:

• Vapor Pressure: 0.000154mmHg at 25°C
• Refractive Index: 1.57
• Boiling Point: 331.6°Cat760mmHg
• Flash Point: 154.3°C
• PSA: 52.60000
• Density: 1.526g/cm³
• LogP: 2.19550
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 271.96842
• Heavy Atom Count: 15
• Complexity: 244

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-formyl-6-methoxyphenyl Acetate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1=C(C=C(C=C1Br)C=O)OC

Technology Process of 2-Bromo-4-formyl-6-methoxyphenyl acetate

There total 1 articles about 2-Bromo-4-formyl-6-methoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-hydroxy-3-methoxybenzaldehyde (2973-76-4) + acetic anhydride (108-24-7) → 4-acetoxy-3-bromo-5-methoxybenzaldehyde (308088-29-1)

Guidance literature:

DOI:10.1039/jr9440000535

Reference yield: 84.0%

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) + 4-acetoxy-3-bromo-5-methoxybenzaldehyde (308088-29-1) + malononitrile (109-77-3) → 4-(2-amino-3-cyano-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolin-4-yl)-2-bromo-6-methoxyphenyl acetate (1019060-12-8)

Guidance literature:

With triethylamine; In ethanol; for 0.833333h; Heating;

DOI:10.1021/jm701499n

Reference yield: 83.0%

4-hydroxy-1,6-dimethylpyridin-2(1H)-one (6052-75-1) + 4-acetoxy-3-bromo-5-methoxybenzaldehyde (308088-29-1) + malononitrile (109-77-3) → 4-(2-amino-3-cyano-6,7-dimethyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]pyridin-4-yl)-2-bromo-6-methoxyphenyl acetate

Guidance literature:

With triethylamine; In ethanol; for 0.833333h; Heating;

DOI:10.1016/j.bmcl.2007.05.004 DOI:10.1021/jm701499n

upstream raw materials:

5-bromo-4-hydroxy-3-methoxybenzaldehyde

acetic anhydride

Downstream raw materials:

2-Amino-4-(4-acetoxy-3-bromo-5-methoxyphenyl)-3-cyano-7-methyl-4H-pyrrolo[2,3-h]chromene

4-(2-amino-3-cyano-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolin-4-yl)-2-bromo-6-methoxyphenyl acetate