phenyl (6-methylpyridin-3-yl)carbamate hydrochloride

Base Information

• Chemical Name: phenyl (6-methylpyridin-3-yl)carbamate hydrochloride
• CAS No.: 1628206-34-7
• Molecular Formula: C₁₃H₁₂N₂O₂*ClH
• Molecular Weight: 264.711
• Mol file: 1628206-34-7.mol

Synonyms:phenyl (6-methylpyridin-3-yl)carbamate hydrochloride

Chemical Property of phenyl (6-methylpyridin-3-yl)carbamate hydrochloride

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl (6-methylpyridin-3-yl)carbamate hydrochloride

There total 1 articles about phenyl (6-methylpyridin-3-yl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-Amino-2-methylpyridine (80287-53-2,3430-14-6) + phenyl chloroformate (1885-14-9) → phenyl (6-methylpyridin-3-yl)carbamate hydrochloride (1628206-34-7)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 20 - 30 ℃; for 6h; Inert atmosphere; Industrial scale;

DOI:10.1021/acs.oprd.9b00200

Reference yield: 89.0%

methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate (873697-70-2) + phenyl (6-methylpyridin-3-yl)carbamate hydrochloride (1628206-34-7) → 4-[2-fluoro-3-[3-(6-methylpyridin-3-yl)ureido]benzyl]piperazine-1-carboxylic acid methyl ester dihydrochloride

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 65 ℃; for 22h; Inert atmosphere; Large scale;

Reference yield: 82.0%

methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate (873697-70-2) + phenyl (6-methylpyridin-3-yl)carbamate hydrochloride (1628206-34-7) → methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate (873697-71-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 57 ℃; for 21h; Industrial scale;

DOI:10.1021/acs.oprd.9b00200

upstream raw materials:

5-Amino-2-methylpyridine

phenyl chloroformate

Downstream raw materials:

methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND THEIR USES". Paragraph 0116; 0117. . Retrieved 2014/10/04.