Technology Process of (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate
There total 6 articles about (S)-methyl 3-(3-hydroxypyrrolidin-1-yl)-2-phenylquinoxaline-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide; toluene;
at 100 ℃;
for 7h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C
2.1: ammonium chloride; iron / water; methanol / 5 h / Reflux
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C
4.1: phosphorus(V) oxybromide / acetonitrile / Reflux
4.2: pH 7 - 8
5.1: N-ethyl-N,N-diisopropylamine / toluene; dimethyl sulfoxide / 7 h / 100 °C / Sealed tube
With
iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide;
In
1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 3 h / 0 °C / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C
3.1: ammonium chloride; iron / water; methanol / 5 h / Reflux
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C
5.1: phosphorus(V) oxybromide / acetonitrile / Reflux
5.2: pH 7 - 8
6.1: N-ethyl-N,N-diisopropylamine / toluene; dimethyl sulfoxide / 7 h / 100 °C / Sealed tube
With
thionyl chloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide;
In
1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;