2-(4-methoxyphenyl)-2-methylpropanal

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-2-methylpropanal
• CAS No.: 32454-14-1
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Mol file: 32454-14-1.mol

Synonyms:2-(4-methoxyphenyl)-2-methylpropanal

Chemical Property of 2-(4-methoxyphenyl)-2-methylpropanal

Chemical Property:

Purity/Quality:

2-(4-methoxyphenyl)-2-methylpropanal 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-2-methylpropanal

There total 22 articles about 2-(4-methoxyphenyl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4-methoxy-phenyl)-2-methyl-propionitrile (5351-07-5) → 2-(4-methoxyphenyl)-2-methylpropanal (32454-14-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.75h;

DOI:10.1055/s-2007-983776

Reference yield: 89.0%

2-Cyclohexyl-3-(4-methoxy-phenyl)-4,4-dimethyl-[1,2]thiazetidine 1,1-dioxide → 2-(4-methoxyphenyl)-2-methylpropanal (32454-14-1)

Guidance literature:

With ethylaluminum dichloride; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/0040-4039(94)02183-C

Reference yield: 75.0%

1-bromo-4-methoxy-benzene (104-92-7) + isovaleraldehyde (590-86-3) → 2-(4-methoxyphenyl)-2-methylpropanal (32454-14-1)

Guidance literature:

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; In tetrahydrofuran; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c5ob01882j

upstream raw materials:

2-iodo-1-(4-methoxy-phenyl)-2-methyl-propan-1-ol

2-(4-methoxy-phenyl)-2-methyl-propan-1-ol

2-(4-methoxyphenyl)-2-methylpropanoic acid

1-methoxy-4-(2-methyl-1-propenyl)benzene

Downstream raw materials:

4-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole

3-(4-Methoxyphenyl)-3-methylbutyronitrile

4-(1,1-Dimethyl-2-butynyl)anisole

Refernces

• 1、 McDonald, Benjamin R.,Scheidt, Karl A.. "Intermolecular Reductive Couplings of Arylidene Malonates via Lewis Acid/Photoredox Cooperative Catalysis". supporting information. p. 6877 - 6881. Retrieved 2018/11/02.
• 2、 Wang, Zhi-Ming,Sang, Xue-Ling,Che, Chi-Ming,Chen, Jian. "Ruthenium(IV) porphyrin catalyzed highly selective oxidation of internal alkenes into ketones with Cl2pyNO as terminal oxidant". supporting information. p. 1736 - 1739. Retrieved 2014/03/21.