2-Bromo-2,3,3,3-tetrafluoropropanamide

Base Information

• Chemical Name: 2-Bromo-2,3,3,3-tetrafluoropropanamide
• CAS No.: 422-22-0
• Molecular Formula: C₃H₂BrF₄NO
• Molecular Weight: 223.953
• Hs Code.: 2924199090
• European Community (EC) Number: 651-687-4
• DSSTox Substance ID: DTXSID80371326
• Mol file: 422-22-0.mol

Synonyms:2-bromo-2,3,3,3-tetrafluoropropanamide;422-22-0;2-Bromo-2,3,3,3-tetrafluoropropionamide;2-Bromotetrafluoropropionamide;2-Bromotetrafluoropropanamide;DTXSID80371326;MFCD00153719;STK449957;AKOS001032261;AKOS016874710;CS-0452332;FT-0611391;A825813;2-bromanyl-2,3,3,3-tetrakis(fluoranyl)propanamide;Z56762203;2-Bromo-2,3,3,3-tetrafluoropropanamidevvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv

Chemical Property of 2-Bromo-2,3,3,3-tetrafluoropropanamide

Chemical Property:

• Vapor Pressure: 1.2mmHg at 25°C
• Melting Point: 83 °C
• Refractive Index: 1.403
• Boiling Point: 174.5°Cat760mmHg
• PKA: 12.45±0.50(Predicted)
• Flash Point: 59.3°C
• PSA: 43.09000
• Density: 1.965g/cm³
• LogP: 1.79500
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 222.92559
• Heavy Atom Count: 10
• Complexity: 157

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-2,3,3,3-tetrafluoropropionamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=O)(C(C(F)(F)F)(F)Br)N

Technology Process of 2-Bromo-2,3,3,3-tetrafluoropropanamide

There total 5 articles about 2-Bromo-2,3,3,3-tetrafluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-bromohexafluoropropyl fluorosulfate (41255-95-2) → 2-bromo-2,3,3,3-tetrafluoropropionamide (422-22-0)

Guidance literature:

With ammonia; In diethyl ether; at 0 ℃; for 5h;

DOI:10.1007/BF00952946

Reference yield: 68.0%

2,3,3,3-tetrafluoro-2-bromopropanoyl fluoride (6129-62-0) → 2-bromo-2,3,3,3-tetrafluoropropionamide (422-22-0)

Guidance literature:

With ammonia; In diethyl ether; at -50 - 20 ℃;

DOI:10.1007/BF00952946

Reference yield:

2-bromo-2,3,3,3-tetrafluoropropionic acid ethyl ester (10186-73-9) → 2-bromo-2,3,3,3-tetrafluoropropionamide (422-22-0)

Guidance literature:

With ammonia; In diethyl ether;

upstream raw materials:

2-bromo-2,3,3,3-tetrafluoro-propionic acid methyl ester

2-bromo-2,3,3,3-tetrafluoropropionic acid ethyl ester

2-bromohexafluoropropyl fluorosulfate

2,3,3,3-tetrafluoro-2-bromopropanoyl fluoride

Refernces