4'-FLUOROVALEROPHENONE

Base Information

• Chemical Name: 4'-FLUOROVALEROPHENONE
• CAS No.: 29114-66-7
• Molecular Formula: C11H13FO
• Molecular Weight: 180.222
• Hs Code.: 29147000
• Mol file: 29114-66-7.mol

Synonyms:Valerophenone,2-fluoro- (8CI);1-(4-fluorophenyl)pentan-1-one;1-(4-Fluoro-phenyl)-pentan-1-one;1-pentanone, 1-(4-fluorophenyl)-;1-(4-fluorophenyl)pentan-1-one;

Chemical Property of 4'-FLUOROVALEROPHENONE

Chemical Property:

• Appearance/Colour: colorless adhering crystalline solid
• Vapor Pressure: 0.0186mmHg at 25°C
• Melting Point: 23-25 °C
• Refractive Index: 1.4970
• Boiling Point: 253.1 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 17.07000
• Density: 1.031 g/cm³
• LogP: 3.19860
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Hexanes (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

4''-Fluorovalerophenone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4''-Fluorovalerophenone (CAS:709-24-0) is a useful research compound.

Technology Process of 4'-FLUOROVALEROPHENONE

There total 10 articles about 4'-FLUOROVALEROPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-fluoro-1-phenyl-2-(phenylsulfinyl)-1-pentanone (138042-63-4) → 1-phenyl-2-fluoropentan-1-one (29114-66-7)

Guidance literature:

With ethylmagnesium bromide; In diethyl ether; at -78 ℃; for 0.0833333h;

DOI:10.1246/bcsj.65.2800

Reference yield: 71.0%

1-phenyl-1-pentylhydrazone → 1-phenyl-2-fluoropentan-1-one (29114-66-7)

Guidance literature:

With Selectfluor; In acetonitrile; at 70 ℃; for 16h; Sealed tube;

Reference yield: 12.0%

1-phenyl-1-pentyne (4250-81-1) → α,α-diflourovalerophenone (58534-47-7) + 1-phenyl-2-fluoropentan-1-one (29114-66-7) + 1-phenyl-1,1-difluoropentan-2-one (110097-48-8) + 1-phenyl-1,1-dimethoxy-2,2-difluoropentane (110097-45-5)

Guidance literature:

With methanol; calcium sulfate; for 1h; Further byproducts given; Ambient temperature;

DOI:10.1021/jo00231a034

upstream raw materials:

ethyl 2-fluoropentanoate

methanol

1-phenyl-1-pentyne

4-fluoro-1-phenyl-2-(phenylsulfinyl)-1-pentanone

Downstream raw materials:

1,1-Dimethoxy-1-phenyl-pentan-2-one

2-Bromo-2-fluoro-1-phenyl-pentan-1-one

α,α-diflourovalerophenone

2-fluoroacetophenone

Refernces

• 1、 Satoh, Tsuyoshi,Itoh, Norifumi,Onda, Ken-ichi,Kitoh, Yasushi,Yamakawa, Koji. "1-Haloalkyl Aryl Sulfoxides as Useful Agents in Synthesis of α-Halo Ketones: A New Synthesis of α-Halo Ketones, α-Halo α,β-Unsaturated Ketones, and α-Halo Cross Dienones from Aldehydes". . p. 2800 - 2806. Retrieved 2007/10/02.
• 2、 Stavber, Stojan,Zupan, Marko. "Room-Temperature Fluorination of 1-Phenylacetylenes with Cesium Fluoroxysulfate". . p. 5022 - 5025. Retrieved 2007/10/02.