9-BroMo-16α,17-epoxy-11β-hydroxyprogesterone

Base Information

• Chemical Name: 9-BroMo-16α,17-epoxy-11β-hydroxyprogesterone
• CAS No.: 110053-24-2
• Molecular Formula: C₂₁H₂₇BrO₄
• Molecular Weight: 423.347
• Mol file: 110053-24-2.mol

Synonyms:9-bromo-16α,17-epoxy-11β-hydroxy-pregn-4-ene-3,20-dione

Chemical Property of 9-BroMo-16α,17-epoxy-11β-hydroxyprogesterone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 9-Bromo-16α,17-epoxy-11β-hydroxyprogesterone is an halogenated intermediate in the synthesis of 16-Hydroxycorticosterone 20-Hydroxy-21-Acid (H918430), an oxidized derivative of corticosterone (C695700).

Technology Process of 9-BroMo-16α,17-epoxy-11β-hydroxyprogesterone

There total 2 articles about 9-BroMo-16α,17-epoxy-11β-hydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

16α,17α-epoxypregna-4,9(11)-dien-3,20-dione (94088-90-1) → 9-bromo-16α,17-epoxy-11β-hydroxy-pregn-4-ene-3,20-dione (110053-24-2)

Guidance literature:

With 1,4-dioxane; N-Bromosuccinimide; perchloric acid; water;

DOI:10.1021/ja01527a049

Reference yield:

N-Bromosuccinimide (128-08-5) + perchloric acid (7601-90-3) + 16α,17α-epoxypregna-4,9(11)-dien-3,20-dione (94088-90-1) → 9-bromo-16α,17-epoxy-11β-hydroxy-pregn-4-ene-3,20-dione (110053-24-2)

Guidance literature:

DOI:10.1021/ja01527a049

Reference yield:

9-bromo-16α,17-epoxy-11β-hydroxy-pregn-4-ene-3,20-dione (110053-24-2) → 9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione (2135-14-0)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium acetate; ethanol

2: dichloromethane; tetrahydrofuran; hydrogen fluoride / -60 °C

3: CrCl₂; acetic acid / Erwaermen des Reaktionsprodukts mit HCl in Aceton und CHCl₃

4: OsO₄

5: nocardia corallina

6: hydrochloric acid; acetone

With tetrahydrofuran; chromium dichloride; hydrogenchloride; osmium(VIII) oxide; ethanol; dichloromethane; nocardia corallina; hydrogen fluoride; potassium acetate; acetic acid; acetone;

DOI:10.1021/ja01527a049

upstream raw materials:

16α,17α-epoxypregna-4,9(11)-dien-3,20-dione

N-Bromosuccinimide

perchloric acid

Downstream raw materials:

9α-fluoro-11β-hydroxy-4,16-dienepregna-3,20-dione

9-fluoro-11β,16α,17-trihydroxy-pregna-1,4-diene-3,20-dione

9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione