Technology Process of (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol
There total 9 articles about (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium tungstate; dihydrogen peroxide;
In
toluene;
at 60 ℃;
for 1h;
DOI:10.1246/bcsj.69.2625
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
2: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C
3: Et3N / toluene / 0.5 h / 0 °C
4: 15percent aq. KOH / toluene / 2 h / 0 °C
5: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
6: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
With
titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; potassium hydroxide; sodium hydroxide; sodium tungstate; diethyl (2S,3S)-tartrate; dihydrogen peroxide; triethylamine;
In
dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1246/bcsj.69.2625
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / Bu4NF / tetrahydrofuran / 1 h / 0 °C
2: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
3: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C
4: Et3N / toluene / 0.5 h / 0 °C
5: 15percent aq. KOH / toluene / 2 h / 0 °C
6: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
7: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
With
titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; potassium hydroxide; sodium hydroxide; sodium tungstate; diethyl (2S,3S)-tartrate; tetrabutyl ammonium fluoride; dihydrogen peroxide; triethylamine;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1246/bcsj.69.2625