Technology Process of 2-hydroxy-5-propylphenylboronic acid
There total 3 articles about 2-hydroxy-5-propylphenylboronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-4-propylphenol;
With
n-butyllithium;
In
diethyl ether; hexane;
at 20 ℃;
for 2h;
Cooling;
Inert atmosphere;
Trimethyl borate;
In
diethyl ether; hexane;
at 20 ℃;
for 15.5h;
Cooling;
Inert atmosphere;
With
hydrogenchloride;
In
diethyl ether; hexane; water;
for 0.5h;
Cooling with ice;
DOI:10.1016/j.bmc.2014.10.027
- Guidance literature:
-
2-bromo-4-propylphenol;
With
n-butyllithium;
In
diethyl ether;
at -78 ℃;
With
Trimethyl borate;
In
diethyl ether;
at -78 - 20 ℃;
With
hydrogenchloride;
In
diethyl ether;
DOI:10.1021/ml300235q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate; bromine / chloroform / 0 °C
2.1: n-butyllithium / diethyl ether / -78 °C
2.2: -78 - 20 °C
With
n-butyllithium; bromine; sodium hydrogencarbonate;
In
diethyl ether; chloroform;
DOI:10.1021/ml300235q
