2-METHOXYPHENYLSULFONYLETHANOL

Base Information

• Chemical Name: 2-METHOXYPHENYLSULFONYLETHANOL
• CAS No.: 75259-57-3
• Molecular Formula: C₉H₁₂O₄S
• Molecular Weight: 216.258
• Mol file: 75259-57-3.mol

Synonyms:2-((2-methoxyphenyl)sulfonyl)ethanol

Chemical Property of 2-METHOXYPHENYLSULFONYLETHANOL

Chemical Property:

• Melting Point: 110-112°C

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxyphenylsulfonylethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHOXYPHENYLSULFONYLETHANOL

There total 3 articles about 2-METHOXYPHENYLSULFONYLETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-methanesulfonyl-2-methoxy-benzene (13736-79-3) → 2-((2-methoxyphenyl)sulfonyl)ethanol (75259-57-3)

Guidance literature:

With n-propylmagnesium bromide; In tetrahydrofuran; 1.) room temp., 1 h; 2.) reflux;

Reference yield:

1-methoxy-2-(methylsulfanyl)benzene (2388-73-0) → 2-((2-methoxyphenyl)sulfonyl)ethanol (75259-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

1,2-bis-(2-methoxy-benzenesulfonyl)-ethane (145917-57-3) → 2-((2-methoxyphenyl)sulfonyl)ethanol (75259-57-3)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

1,2-bis-(2-methoxy-benzenesulfonyl)-ethane

formaldehyd

1-methanesulfonyl-2-methoxy-benzene

1-methoxy-2-(methylsulfanyl)benzene

Refernces

• 1、 Fournier,Loiseau,Moreau,et al.. "Hypolipemic (2-hydroxyalkyl)- and (3-hydroxyalkyl)-phenylsulfones". . p. 53 - 58. Retrieved 2007/10/02.