(S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide

Base Information

• Chemical Name: (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide
• CAS No.: 1426847-87-1
• Molecular Formula: BrH*C₁₀H₁₄N₂O₄
• Molecular Weight: 307.144
• Mol file: 1426847-87-1.mol

Synonyms:(S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide

Chemical Property of (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide

There total 1 articles about (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-benzyl 2-(3-(3,4-dimethoxyphenyl)-1-(pentan-3-yloxy)-2-methyl-1-oxopropan-2-yl)hydrazinecarboxylate (1281895-88-2) → (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide (1426847-87-1)

Guidance literature:

(S)-benzyl 2-(3-(3,4-dimethoxyphenyl)-1-(pentan-3-yloxy)-2-methyl-1-oxopropan-2-yl)hydrazinecarboxylate; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 24h; Inert atmosphere;

With methanol; at 50 ℃; for 12h;

DOI:10.1021/ol400136y

Reference yield:

(S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrobromide (1426847-87-1) → carbidopa monohydrate (38821-49-7)

Guidance literature:

With dimethyl amine; In tetrahydrofuran; isopropyl alcohol; pH=6.4;

DOI:10.1021/ol400136y

upstream raw materials:

(S)-benzyl 2-(3-(3,4-dimethoxyphenyl)-1-(pentan-3-yloxy)-2-methyl-1-oxopropan-2-yl)hydrazinecarboxylate

Downstream raw materials:

carbidopa monohydrate

Refernces