2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene

Base Information

• Chemical Name: 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene
• CAS No.: 496801-01-5
• Molecular Formula: C₂₀H₂₀O₄S
• Molecular Weight: 356.442
• Mol file: 496801-01-5.mol

Synonyms:2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene

Chemical Property of 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene

There total 3 articles about 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2,3-dimethoxythiophene (51792-34-8) + benzaldehyde (100-52-7) → (3,4-dimethoxy-thiophen-2-yl)-phenyl-methanol + 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene (496801-01-5)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; for 0.25h; Heating;

DOI:10.1016/j.tet.2004.09.008

Reference yield:

3,4-dimethoxythiophene-2,5-dicarboxylic acid (177364-96-4) → 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene (496801-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / copper chromite; quinoline / 4 h / 160 °C

2: 23 percent / N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran / 0.25 h / Heating

With quinoline; copper chromite; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.09.008

Reference yield:

benzaldehyde (100-52-7) + 3,4-dimethoxy-2,5-dilithiothiophene → (3,4-dimethoxy-thiophen-2-yl)-phenyl-methanol + 2,5-bis-(phenylhydroxymethyl)-3,4-dimethoxythiophene (496801-01-5)

Guidance literature:

In tetrahydrofuran;

DOI:10.1039/b208017f

upstream raw materials:

benzaldehyde

2,3-dimethoxythiophene

3,4-dimethoxythiophene-2,5-dicarboxylic acid

Downstream raw materials:

5,15,10,20-tetraphenylporphyrin

Refernces

• 1、 Agarwal, Neeraj,Mishra, Sarada P.,Kumar, Anil,Hung,Ravikanth. "Synthesis and crystal structure of 2,3,12,13-tetraalkoxy-21,23-dithiaporphyrins". . p. 2642 - 2643. Retrieved 2007/10/03.