Technology Process of 4-Nitro-benzoic acid (1R,4R,5R,6R)-4,5,6-tris-methoxymethoxy-cyclohex-2-enyl ester
There total 19 articles about 4-Nitro-benzoic acid (1R,4R,5R,6R)-4,5,6-tris-methoxymethoxy-cyclohex-2-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
DOI:10.1039/a905462f
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 94 percent / Huenig base / CH2Cl2
2: 95 percent / OsO4; NMO / tetrahydrofuran; H2O
3: 95 percent / Huenig base / CH2Cl2
4: 93 percent / H2 / Pd/C / ethyl acetate
5: 90 percent / I2; PPh3; imidazole / tetrahydrofuran
6: 96 percent / Zn / acetic acid; methanol / 20 °C
7: 61 percent / LDA / tetrahydrofuran / -78 - 20 °C
8: H2; quinoline / Pd/BaSO4 / ethyl acetate
9: Grubbs' catalyst / benzene / Heating
10: PPh3; DIAD / tetrahydrofuran
With
1H-imidazole; quinoline; osmium(VIII) oxide; N-methyl-2-indolinone; di-isopropyl azodicarboxylate; hydrogen; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; lithium diisopropyl amide;
palladium on activated charcoal; Pd-BaSO4; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;
10: Mitsunobu reaction;
DOI:10.1021/ol015963x
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 90 percent / NaBH4; CeCl3 / 0 °C
2: 94 percent / Huenig base / CH2Cl2
3: 95 percent / OsO4; NMO / tetrahydrofuran; H2O
4: 95 percent / Huenig base / CH2Cl2
5: 93 percent / H2 / Pd/C / ethyl acetate
6: 90 percent / I2; PPh3; imidazole / tetrahydrofuran
7: 96 percent / Zn / acetic acid; methanol / 20 °C
8: 61 percent / LDA / tetrahydrofuran / -78 - 20 °C
9: H2; quinoline / Pd/BaSO4 / ethyl acetate
10: Grubbs' catalyst / benzene / Heating
11: PPh3; DIAD / tetrahydrofuran
With
1H-imidazole; quinoline; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; cerium(III) chloride; di-isopropyl azodicarboxylate; hydrogen; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; lithium diisopropyl amide;
palladium on activated charcoal; Pd-BaSO4; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;
11: Mitsunobu reaction;
DOI:10.1021/ol015963x