Boc-Tra-Phe-isonicotinylaminomethyl ketone

Base Information

• Chemical Name: Boc-Tra-Phe-isonicotinylaminomethyl ketone
• CAS No.: 152438-42-1
• Molecular Formula: C₂₉H₄₀N₄O₄
• Molecular Weight: 508.661
• Mol file: 152438-42-1.mol

Synonyms:Boc-Tra-Phe-isonicotinylaminomethyl ketone

Chemical Property of Boc-Tra-Phe-isonicotinylaminomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tra-Phe-isonicotinylaminomethyl ketone

There total 7 articles about Boc-Tra-Phe-isonicotinylaminomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.6%

4-(Methylamino)pyridine (1121-58-0) + Boc-Tra-Phe-CH2Cl (152438-35-2) → Boc-Tra-Phe-isonicotinylaminomethyl ketone (152438-42-1)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 45 ℃; for 24h;

DOI:10.1248/cpb.41.1079

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Tra-Phe-isonicotinylaminomethyl ketone (152438-42-1)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N

2: 2.) 7.6 N HCl / 1.) THF, 4 deg C, 5 h, 2.) THF, dioxane, -15 deg C, 3 h

3: 7.0 N HCl / dioxane

4: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

5: 5.6 percent / NaI, NaHCO₃ / dimethylformamide / 24 h / 45 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

Reference yield:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → Boc-Tra-Phe-isonicotinylaminomethyl ketone (152438-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

3: 5.6 percent / NaI, NaHCO₃ / dimethylformamide / 24 h / 45 °C

With sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

upstream raw materials:

4-(Methylamino)pyridine

Boc-Tra-Phe-CH₂Cl

N-tert-butoxycarbonyl-L-phenylalanine

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

Refernces