(rac)-N-benzyl-N-methylalanine

Base Information

• Chemical Name: (rac)-N-benzyl-N-methylalanine
• CAS No.: 101692-94-8
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 101692-94-8.mol

Synonyms:(rac)-N-benzyl-N-methylalanine

Chemical Property of (rac)-N-benzyl-N-methylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (rac)-N-benzyl-N-methylalanine

There total 4 articles about (rac)-N-benzyl-N-methylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(N-benzyl-N-methylalanyl)-(S)-prolinol → (rac)-N-benzyl-N-methylalanine (101692-94-8) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9)

Guidance literature:

With hydrogenchloride; In methanol; Heating;

DOI:10.1016/0040-4039(96)00488-1

Reference yield: 72.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-benzylalanine (7585-47-9,40297-69-6,65491-01-2) → (rac)-N-benzyl-N-methylalanine (101692-94-8)

Guidance literature:

With formic acid; In water; at 100 ℃; for 1.5h;

DOI:10.1002/ejoc.200701101

Reference yield:

2-Bromopropionic acid (598-72-1,10327-08-9) + benzyl-methyl-amine (103-67-3) → (rac)-N-benzyl-N-methylalanine (101692-94-8)

Guidance literature:

upstream raw materials:

2-Bromopropionic acid

benzyl-methyl-amine

formaldehyd

N-benzylalanine

Downstream raw materials:

N-methylalanine

Refernces

• 1、 Pandey,Reddy,Das. "Synthesis and utilization of a novel glycine derived chiral precursor, based on a recyclable L-prolinol auxiliary, for the enantioselective preparation of α-amino acids and their N-methyl derivatives". . p. 3175 - 3178. Retrieved 2007/10/03.