4-methyl-3-pentenoic acid phenylamide

Base Information

• Chemical Name: 4-methyl-3-pentenoic acid phenylamide
• CAS No.: 114475-19-3
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 114475-19-3.mol

Synonyms:4-methyl-3-pentenoic acid phenylamide

Chemical Property of 4-methyl-3-pentenoic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 4-methyl-3-pentenoic acid phenylamide

There total 14 articles about 4-methyl-3-pentenoic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

carbon monoxide (201230-82-2) + aniline (62-53-3) + 3-methyl-2-buten-1-ol (556-82-1) → 4-methyl-3-pentenoic acid phenylamide (114475-19-3)

Guidance literature:

With C₂₃H₃₁N; water; palladium dichloride; In toluene; at 100 ℃; for 24h; under 30003 Torr; Autoclave; Inert atmosphere;

DOI:10.1002/chem.201601260

Reference yield: 90.0%

carbon monoxide (201230-82-2) + aniline (62-53-3) + 3,3-dimethyl-allyl chloride (503-60-6) → 4-methyl-3-pentenoic acid phenylamide (114475-19-3)

Guidance literature:

With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 110 ℃; for 12h; under 15514.9 Torr;

DOI:10.1016/j.tetlet.2009.11.023

Reference yield: 80.0%

4-methyl-pent-3-enoic acid (504-85-8) + aniline (62-53-3) → 4-methyl-3-pentenoic acid phenylamide (114475-19-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ja710492q

upstream raw materials:

4-methyl-pent-3-enoic acid

aniline

phenyl isocyanate

isoprene

Downstream raw materials:

2-(3,3-Dimethyl-oxiranyl)-N-phenyl-acetamide

3-hydroxy-4-methyl-N-phenylpentanamide

4-hydroxy-4-methyl-valeric acid anilide

Refernces

• 1、 Fang, Xianjie,Li, Haoquan,Jackstell, Ralf,Beller, Matthias. "Selective palladium-catalyzed aminocarbonylation of 1,3-dienes: Atom-efficient synthesis of β,γ-unsaturated amides". supporting information. p. 16039 - 16043. Retrieved 2015/02/19.
• 2、 Smith, Sean M.,Thacker, Nathan C.,Takacs, James M.. "Efficient amide-directed catalytic asymmetric hydroboration". . p. 3734 - 3735. Retrieved 2008/09/20.