1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole

Base Information

• Chemical Name: 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole
• CAS No.: 78176-05-3
• Molecular Formula: C₂₂H₂₃OP
• Molecular Weight: 334.398
• Mol file: 78176-05-3.mol

Synonyms:1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole

Chemical Property of 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole

There total 6 articles about 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyldiphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphonium iodide (78176-04-2) → 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole (78176-05-3)

Guidance literature:

With sodium hydride; In diethyl ether; for 18h; Ambient temperature;

DOI:10.1021/ja00400a037

Reference yield:

phenyllithium (591-51-5) → 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole (78176-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) aq. NH₄I / 1.) THF, room temperature, 3 h, 2.) 20 min.

2: 80 percent / sodium hydride / diethyl ether / 18 h / Ambient temperature

With ammonium iodide; sodium hydride; In diethyl ether;

DOI:10.1021/ja00400a037

Reference yield:

Dichlorophenylphosphine (644-97-3) → 1,1-diphenyl-1,3,3-trimethyl-3H-2,1-benzoxaphosphole (78176-05-3)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₃MgBr, Mg / tetrahydrofuran; diethyl ether / 1.) reflux, 3 h, 2.) room temperature, 18 h

2: 67 percent / diethyl ether / 24 h

3: 2.) aq. NH₄I / 1.) THF, room temperature, 3 h, 2.) 20 min.

4: 80 percent / sodium hydride / diethyl ether / 18 h / Ambient temperature

With ammonium iodide; methylmagnesium bromide; sodium hydride; magnesium; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja00400a037

upstream raw materials:

methyldiphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphonium iodide

phenyllithium

Dichlorophenylphosphine

2-(2-bromophenyl)propanol

Downstream raw materials:

methyldiphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphonium fluoride

Refernces