2-BROMO-3'-ACETYLOXYLACETOPHENONE

Base Information

• Chemical Name: 2-BROMO-3'-ACETYLOXYLACETOPHENONE
• CAS No.: 38396-89-3
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.084
• Hs Code.: 2915390090
• Mol file: 38396-89-3.mol

Synonyms:Acetophenone,2-bromo-3'-hydroxy-, acetate (7CI);

Chemical Property of 2-BROMO-3'-ACETYLOXYLACETOPHENONE

Chemical Property:

• Boiling Point: 337.7 °C at 760 mmHg
• Flash Point: 158 °C
• PSA: 43.37000
• Density: 1.497 g/cm³
• LogP: 2.18950

Purity/Quality:

99% ^*data from raw suppliers

2-?Bromo-?3''-?acetyloxylacetopheno?ne ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-?Bromo-?3''-?acetyloxylacetopheno?ne was used in the study of preparation of substituted heterocycle compounds enhancing antitumor activity of other cytotoxic agents.

Technology Process of 2-BROMO-3'-ACETYLOXYLACETOPHENONE

There total 4 articles about 2-BROMO-3'-ACETYLOXYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

3-acetylphenyl acetate (2454-35-5) → 2-bromo-3-acetyloxylacetophenone (38396-89-3)

Guidance literature:

With aluminum (III) chloride; bromine; In diethyl ether; at -10 ℃; Solvent; Temperature; Catalytic behavior;

DOI:10.1246/cl.170028

Reference yield:

3-acetylphenyl acetate (2454-35-5) + water (7732-18-5) + sodium hydrogensulfite → 2-bromo-3-acetyloxylacetophenone (38396-89-3)

Guidance literature:

With bromine; In tetrachloromethane;

Reference yield:

3-Hydroxyacetophenone (121-71-1) → 2-bromo-3-acetyloxylacetophenone (38396-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 20 °C

2: bromine; aluminum (III) chloride / diethyl ether / Cooling with ice

With dmap; aluminum (III) chloride; bromine; In diethyl ether; dichloromethane;

DOI:10.1007/s12272-013-0253-9

upstream raw materials:

3-acetylphenyl acetate

water

3-Hydroxyacetophenone

Downstream raw materials:

1-(3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)propan-2-one

C₁₄H₉F₃N₂O

3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol

3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methanesulfonate

Refernces

• 1、 Zhang, Yu-Juan,Shen, Liu-Lan,Cheon, Hyae-Gyeong,Xu, Yong-Nan,Jeong, Jin-Hyun. "Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists". . p. 588 - 599. Retrieved 2014/06/09.