Technology Process of (+/-)(3R*,3aR*,4S*,6aR*)-3,3a,4,6a-tetrahydro-3-methyl-4-<(benzyloxy)methyl>-2H-cyclopentafuran-2-one
There total 6 articles about (+/-)(3R*,3aR*,4S*,6aR*)-3,3a,4,6a-tetrahydro-3-methyl-4-<(benzyloxy)methyl>-2H-cyclopentafuran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH / 1.) benzene, dimethyl sulfoxide, 60 deg C, 4 h, 2.) 8 h
2: 97 percent / 10percent HCl / tetrahydrofuran / 18 h / Ambient temperature
3: NaOH, H2O2 / 1.) THF, CH3OH, H2O, 0 deg C, 1 h, 2.) room temp., 24 h
4: borontrifluoride etherate / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temp., 30 min
5: 1.) lithium diisopropylamide
With
hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00325a035
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaOH, H2O2 / 1.) THF, CH3OH, H2O, 0 deg C, 1 h, 2.) room temp., 24 h
2: borontrifluoride etherate / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temp., 30 min
3: 1.) lithium diisopropylamide
With
sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; lithium diisopropyl amide;
In
dichloromethane;
DOI:10.1021/jo00325a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / 10percent HCl / tetrahydrofuran / 18 h / Ambient temperature
2: NaOH, H2O2 / 1.) THF, CH3OH, H2O, 0 deg C, 1 h, 2.) room temp., 24 h
3: borontrifluoride etherate / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temp., 30 min
4: 1.) lithium diisopropylamide
With
hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate; dihydrogen peroxide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00325a035