cyanocobalamin-b-monocarboxylic acid

Base Information

• Chemical Name: cyanocobalamin-b-monocarboxylic acid
• CAS No.: 38218-77-8
• Molecular Formula: C₆₃H₈₇CoN₁₃O₁₅P
• Molecular Weight: 1356.43
• Mol file: 38218-77-8.mol

Synonyms:Cobinicacid-acdeg-pentamide, cyanide phosphate, 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole,inner salt (7CI); Cobinic acid-acdeg-pentamide, cyanide, dihydrogen phosphate(ester), inner salt, 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole; CBC 195;Cyanocobalamin-b-carboxylic acid

Chemical Property of cyanocobalamin-b-monocarboxylic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 441.98000
• Density: g/cm³
• LogP: 5.23588

Purity/Quality:

99%, ^*data from raw suppliers

Cyanocobalamin-b-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cyancobalamin-b-carboxylic Acid is a Vitamin B12 (V676005) derivative, which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

Technology Process of cyanocobalamin-b-monocarboxylic acid

There total 3 articles about cyanocobalamin-b-monocarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

vitamin B12 (8039-03-0) + water (7732-18-5) → Vitamin B12-b-acid (38218-77-8)

Guidance literature:

With HCl; In water; Vitamin B12 was hydrolyzed in 0.1 M HCl;

DOI:10.1039/b405575f

Reference yield: 14.9%

vitamin B-12 (8039-03-0) → Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-cyanocobamic acid a,b,c,d,g-pentamide (26264-28-8) + Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-cyanocobamic acid a,c,d,e,g-pentamide (38218-77-8) + Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-cyanocobamic acid a,b,c,e,g-pentamide

Guidance literature:

With HCl; In hydrogenchloride; a soln. of cyanocobalamin in 1 M HCl incubated at 37°C for 4 h; neutralized with NaOH; desalted by phenol extraction; concentrated; chromy.; collected; desalted; crystd. from aq. acetone;

DOI:10.1021/ja00527a011

Reference yield: 7.0%

vitamin B-12 (8039-03-0) + water (7732-18-5) → Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-cyanocobamic acid a,c,d,e,g-pentamide (38218-77-8) + Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-cyanocobamic acid a,b,c,e,g-pentamide

Guidance literature:

In hydrogenchloride; vitamin B12 hydrolized in 0.1 M HCl; decanted. chromy.(DOWEX), chromy.(HPLC-RP8 - sodium buffer A/CH3OH/H2O, 2-amino-2-(hydroxymethyl)propane-1,3-diol/H2O/CH3CN/CH3OH);

DOI:10.1002/ejic.200601195

upstream raw materials:

vitamin B-12

water

vitamin B₁₂

Refernces

• 1、 -. "COBALAMINE DERIVATIVES USEFUL FOR DIAGNOSIS AND TREATMENT OF ABNORMAL CELLULAR PROLIFERATION". Page/Page column 18-19. . Retrieved 2008/06/13.
• 2、 Anton,Hogenkamp,Walker,Matwiyoff. "Carbon-13 nuclear magnetic resonance studies of the monocarboxylic acids of cyanocobalamin. Assignments of the b-, d-, and e-monocarboxylic acids". . p. 2215 - 2219. Retrieved 2007/10/02.