N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol

Base Information

• Chemical Name: N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol
• CAS No.: 1448706-80-6
• Molecular Formula: C₁₅H₂₅NO₅
• Molecular Weight: 299.367
• Mol file: 1448706-80-6.mol

Synonyms:N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol

Chemical Property of N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol

There total 1 articles about N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

glycolaldehyde dimer (23147-58-2,110822-84-9,110822-85-0,77431-49-3) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) + N-(methyl)aminoacetaldehyde dimethyl acetal (122-07-6) → N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol (1448706-80-6)

Guidance literature:

glycolaldehyde dimer; 3,4-Dimethoxyphenylboronic acid; In dichloromethane; water; at 20 ℃; Inert atmosphere;

N-(methyl)aminoacetaldehyde dimethyl acetal; In dichloromethane; water; at 20 ℃; Inert atmosphere;

DOI:10.3987/COM-12-S(N)59

Reference yield: 84.0%

N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol (1448706-80-6) → N-methyl-2-methoxy-5-(3,4-dimethoxyphenyl)morpholine

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 24h;

DOI:10.3987/COM-12-S(N)59

Reference yield: 81.0%

N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol (1448706-80-6) + benzyl bromide (100-39-0) → O-benzyl-N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol (1448706-87-3)

Guidance literature:

N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol; With potassium hydride; In tetrahydrofuran; paraffin oil; at 0 ℃;

benzyl bromide; In tetrahydrofuran; paraffin oil; at 0 - 20 ℃;

DOI:10.3987/COM-12-S(N)59

upstream raw materials:

glycolaldehyde dimer

3,4-Dimethoxyphenylboronic acid

N-(methyl)aminoacetaldehyde dimethyl acetal

Downstream raw materials:

O-benzyl-N-(2,2-dimethoxyethyl)-N-methyl-2-(3,4-dimethoxyphenyl)glycinol

Refernces