1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE

Base Information

• Chemical Name: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE
• CAS No.: 38025-45-5
• Molecular Formula: C18H19 N
• Molecular Weight: 249.356
• Hs Code.: 2933399090
• Mol file: 38025-45-5.mol

Synonyms:1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE

Chemical Property of 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE

Chemical Property:

• PSA: 3.24000
• LogP: 3.91380
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-4-phenyl-1,2,3,6-tetrahydropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE

There total 17 articles about 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-Benzyl-4-phenyl-pyridinium; bromide (89290-93-7) → 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (38025-45-5)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; triethylammonium formate; potassium iodide; In dichloromethane; at 40 ℃; for 24h; chemoselective reaction; Sealed tube;

DOI:10.1002/adsc.201201034

Reference yield: 91.0%

1-benzyl-4-hydroxy-4-phenylpiperidine (63843-83-4) → 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (38025-45-5)

Guidance literature:

With phosphorus pentoxide; In toluene; Heating;

DOI:10.1016/S0960-894X(00)00703-4

Reference yield: 90.0%

1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (936231-01-5) + iodobenzene (591-50-4) → 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (38025-45-5)

Guidance literature:

With tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/ol070241c

upstream raw materials:

3-benzyl-6-methyl-6-phenyl-[1,3]oxazinane

1-benzyl-4-hydroxy-4-phenylpiperidine

1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

iodobenzene

Downstream raw materials:

1-ethoxycarbonyl-4-phenyl-1,2,5,6-tetrahydropyridine

1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride

4-phenylpiperidine hydrochloride

1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride

Refernces

• 1、 Romero-Iba?ez, Julio,Cruz-Gregorio, Silvano,Sandoval-Lira, Jacinto,Hernández-Pérez, Julio M.,Quintero, Leticia,Sartillo-Piscil, Fernando. "Transition-Metal-Free Deconstructive Lactamization of Piperidines". supporting information. p. 8867 - 8871. Retrieved 2019/05/28.
• 2、 Wu, Jianjun,Tang, Weijun,Pettman, Alan,Xiao, Jianliang. "Efficient and chemoselective reduction of pyridines to tetrahydropyridines and piperidines via rhodium-catalyzed transfer hydrogenation". supporting information. p. 35 - 40. Retrieved 2013/03/13.