(4-dimethylamino-phenyl)-phosphonous acid dichloride

Base Information

• Chemical Name: (4-dimethylamino-phenyl)-phosphonous acid dichloride
• CAS No.: 29972-74-5
• Molecular Formula: C₈H₁₀Cl₂NP
• Molecular Weight: 222.054
• Mol file: 29972-74-5.mol

Synonyms:(4-dimethylamino-phenyl)-phosphonous acid dichloride

Chemical Property of (4-dimethylamino-phenyl)-phosphonous acid dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-dimethylamino-phenyl)-phosphonous acid dichloride

There total 7 articles about (4-dimethylamino-phenyl)-phosphonous acid dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N-dimethyl-aniline (121-69-7,77733-26-7) → (4-dimethylamino-phenyl)-phosphonous acid dichloride (29972-74-5)

Guidance literature:

With pyridine; phosphorus trichloride; at 0 - 115 ℃; Inert atmosphere;

DOI:10.1002/chem.200902715

Reference yield:

(4-(dimethylamino)phenyl)zinc(II) chloride (93296-10-7) → (4-dimethylamino-phenyl)-phosphonous acid dichloride (29972-74-5)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.1c01560

Reference yield:

4-bromo-N,N-dimethylaniline (586-77-6) → (4-dimethylamino-phenyl)-phosphonous acid dichloride (29972-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: crude xylene; acetic acid ester; sodium amalgam

2: benzene; phosphorus trichloride / man erhitzt am Schluss der Reaktion im Druckrohr auf 130grad

With sodium amalgam; acetic acid ester; crude xylene; phosphorus trichloride; benzene;

upstream raw materials:

4,4'-mercuriobis(N,N-dimethylaniline)

N,N-dimethyl-aniline

phosphorus trichloride

4-bromo-N,N-dimethylaniline

Downstream raw materials:

dimethylphosphine

(4-dimethylamino-phenyl)-phosphonous acid dimethyl ester

4-N,N-dimethylaminophenylphosphinic acid

4-(N,N-Dimethylamino)triphenylphosphine

Refernces

• 1、 Kirst, Christin,Tietze, Jonathan,Ebeling, Marian,Horndasch, Lukas,Karaghiosoff, Konstantin. "The Formation of P-C Bonds Utilizing Organozinc Reagents for the Synthesis of Aryl- A nd Heteroaryl-Dichlorophosphines". . p. 17337 - 17343. Retrieved 2021/11/18.
• 2、 Wang, Fen,Schwabacher, Alan W.. "Tuning of Binding Selectivity: Metal Control of Organic Guest Binding and Allosteric Perturbation of Fluorescent Metal Sensor". . p. 8922 - 8928. Retrieved 2007/10/03.