N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide

Base Information

• Chemical Name: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide
• CAS No.: 1610785-01-7
• Molecular Formula: C₁₄H₁₄ClN₅O₄
• Molecular Weight: 351.749
• Mol file: 1610785-01-7.mol

Synonyms:N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide

Chemical Property of N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide

There total 4 articles about N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-(aminomethyl)-2-methylpyrimidin-4-amine (95-02-3) + 2-(2-chloro-4-nitrophenoxy)acetic acid (5037-04-7) → N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide (1610785-01-7)

Guidance literature:

2-(2-chloro-4-nitrophenoxy)acetic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -5 ℃;

5-(aminomethyl)-2-methylpyrimidin-4-amine; In tetrahydrofuran; N,N-dimethyl-formamide; at -5 - 20 ℃; for 12h;

DOI:10.1016/j.bmc.2014.04.003

Reference yield:

5‐(azidomethyl)‐2‐methylpyrimidin‐4‐amine (63423-50-7) → N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide (1610785-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / -5 °C

2.2: 12 h / -5 - 20 °C

With palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmc.2014.04.003

Reference yield:

2-chloro-4-nitrophenol (619-08-9) → N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-chloro-4-nitrophenoxy)acetamide (1610785-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 70 °C

2.1: sodium hydroxide / acetone / 20 °C

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / -5 °C

3.2: 12 h / -5 - 20 °C

With chloroformic acid ethyl ester; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; acetone;

DOI:10.1016/j.bmc.2014.04.003

upstream raw materials:

5‐(azidomethyl)‐2‐methylpyrimidin‐4‐amine

5-(aminomethyl)-2-methylpyrimidin-4-amine

2-(2-chloro-4-nitrophenoxy)acetic acid

2-chloro-4-nitrophenol

Refernces