(+/-)-estrone methyl ether

Base Information

• Chemical Name: (+/-)-estrone methyl ether
• CAS No.: 1091-94-7
• Molecular Formula: C₁₉H₂₄O₂
• Molecular Weight: 284.398
• Mol file: 1091-94-7.mol

Synonyms:(+/-)-estrone methyl ether

Chemical Property of (+/-)-estrone methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-estrone methyl ether

There total 72 articles about (+/-)-estrone methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) + 3-bromophenyltrimethylammonium iodide → O-methyl-estrone (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h; Solvent;

DOI:10.1039/d1sc00757b

Reference yield: 84.0%

estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) + N,N,N,2-tetramethylbenzenaminium iodide (35616-23-0) → O-methyl-estrone (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h;

DOI:10.1039/d1sc00757b

Reference yield: 65.0%

(+-)-estrone (1187829-63-5) + carbonic acid dimethyl ester (616-38-6) → 3-methoxy-estra-1,3,5(10)-trien-17-one (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 100 ℃; for 8h;

DOI:10.1055/s-1986-31642

upstream raw materials:

(+-)-estrone

carbonic acid dimethyl ester

estrone

methyl iodide

Downstream raw materials:

(+/-)-3-methoxy-13-methyl-(13r,14c)-11,12,13,14,15,16-hexahydro-cyclopenta[a]phenanthren-17-one

(2S,3S)-2-[3-(2-Dimethylaminomethyl-3-methoxy-phenyl)-3-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

3-Methoxy-oestratetraen-(1.3.5(10).16)

{2-Methoxy-6-[3-((1S,5S)-1-methyl-2-oxo-5-vinyl-cyclopentyl)-1-trimethylsilanyl-propyl]-benzyl}-trimethyl-ammonium; iodide

Refernces

• 1、 Zhao, Jianyou,Shen, Tong,Sun, Zhihui,Wang, Nengyong,Yang, Le,Wu, Jintao,You, Huichao,Liu, Zhong-Quan. "Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl". supporting information. p. 4057 - 4061. Retrieved 2021/05/26.
• 2、 -. "HELIX 12 DIRECTED STEROIDAL PHARMACEUTICAL PRODUCTS". Page/Page column 62-63. . Retrieved 2010/02/12.