(+)-(1S,2R)-2-Phenylcyclohexanamine

Base Information

• Chemical Name: (+)-(1S,2R)-2-Phenylcyclohexanamine
• CAS No.: 37982-23-3
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.274
• Mol file: 37982-23-3.mol

Synonyms:(+)-(1S,2R)-2-Phenylcyclohexanamine

Chemical Property of (+)-(1S,2R)-2-Phenylcyclohexanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1S,2R)-2-Phenylcyclohexanamine

There total 42 articles about (+)-(1S,2R)-2-Phenylcyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(RS)-2-phenylcyclohexanone (1444-65-1) → cis-1-amino-2-phenylcyclohexane (1011-11-6,17293-45-7,22147-09-7,37982-23-3,37982-28-8,37982-29-9,40960-61-0,46175-82-0,69743-67-5)

Guidance literature:

With C₂₆H₃₄ClIrN₄O; ammonium formate; acetic acid; In methanol; at 80 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b01565

Reference yield: 79.0%

(RS)-2-phenylcyclohexanone (1444-65-1) + 1-phenylethyl acetate (93-92-5,50373-55-2) → (1R,2S)-1-amino-2-phenylcyclopropane (95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7) + (+)-(1S,2R)-2-Phenylcyclohexanamine (37982-23-3) + (1R,2S)-N-(2-phenylcyclohexyl)acetamide (312611-48-6) + cis-1-amino-2-phenylcyclohexane (1011-11-6,17293-45-7,22147-09-7,37982-23-3,37982-28-8,37982-29-9,40960-61-0,46175-82-0,69743-67-5)

Guidance literature:

(RS)-2-phenylcyclohexanone; With ammonium formate; palladium on activated charcoal; In methanol; water; at 20 ℃;

1-phenylethyl acetate; With Novozyme 435 immobilized on polyacrylamide;

DOI:10.1016/j.tetasy.2005.07.033

Reference yield: 79.0%

(RS)-2-phenylcyclohexanone (1444-65-1) + 1-phenylethyl acetate (93-92-5,50373-55-2) → (1R,2S)-1-amino-2-phenylcyclopropane (95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7) + (+)-(1S,2R)-2-Phenylcyclohexanamine (37982-23-3) + (1R,2S)-N-(2-phenylcyclohexyl)acetamide (312611-48-6) + cis-1-amino-2-phenylcyclohexane (1011-11-6,17293-45-7,22147-09-7,37982-23-3,37982-28-8,37982-29-9,40960-61-0,46175-82-0,69743-67-5)

Guidance literature:

(RS)-2-phenylcyclohexanone; With ammonium formate; palladium on activated charcoal; In methanol; water; at 20 ℃;

1-phenylethyl acetate; With Novozyme 435 immobilized on polyacrylamide;

DOI:10.1016/j.tetasy.2005.07.033

upstream raw materials:

(RS)-2-phenylcyclohexanone

1-phenylethyl acetate

methyl methoxyacetate

trans-2-phenylcyclohexylamine

Downstream raw materials:

(+/-)-chloroacetic acid-(trans-2-phenyl-cyclohexylamide)

(1R,2S)-trans-2-phenylcyclohexylamine

(1R,2S)-N-(2-phenylcyclohexyl)acetamide

(1S,2S)-(+)-cis-2-Phenyl-cyclohexanamin

Refernces

• 1、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.
• 2、 Cheng, Xiaokai,Yang, Bo,Hu, Xingen,Xu, Qing,Lu, Zhan. "Visible-Light-Promoted Metal-Free Aerobic Oxidation of Primary Amines to Acids and Lactones". supporting information. p. 17566 - 17570. Retrieved 2016/11/29.