Technology Process of acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester
There total 5 articles about acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(5-carbamoyl-furan-2-yl)-benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
tris-(dibenzylideneacetone)dipalladium(0); XPhos;
In
1,4-dioxane; water;
at 125 ℃;
for 0.5h;
Microwave irradiation;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 20 h / Reflux
2: N,N-dimethyl-formamide / 6 h / 105 °C
3: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere
5: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere
With
potassium phosphate; N-Bromosuccinimide; potassium acetate; caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; N,N-dimethylethylenediamine; XPhos; dibenzoyl peroxide;
In
1,4-dioxane; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 6 h / 105 °C
2: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere
4: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere
With
potassium phosphate; potassium acetate; caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; N,N-dimethylethylenediamine; XPhos;
In
1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
