phenylacetylaminoacetaldehyde cyanohydrin

Base Information

• Chemical Name: phenylacetylaminoacetaldehyde cyanohydrin
• CAS No.: 371143-24-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Mol file: 371143-24-7.mol

Synonyms:phenylacetylaminoacetaldehyde cyanohydrin

Chemical Property of phenylacetylaminoacetaldehyde cyanohydrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylacetylaminoacetaldehyde cyanohydrin

There total 4 articles about phenylacetylaminoacetaldehyde cyanohydrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

phenylacetylaminoacetaldehyde (5663-61-6) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → phenylacetylaminoacetaldehyde cyanohydrin (371143-24-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0968-0896(01)00107-9

Reference yield:

Benzylpenilloaldehyd-hemihydrat → phenylacetylaminoacetaldehyde cyanohydrin (371143-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 24 h / Heating

2: 57 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

With triethylamine; In dichloromethane; benzene;

DOI:10.1016/S0968-0896(01)00107-9

Reference yield:

phenyl-acetic acid-(2,2-diethoxy-ethylamide) (722479-69-8) → phenylacetylaminoacetaldehyde cyanohydrin (371143-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / diethyl ether / 4 h / 20 °C

2: benzene / 24 h / Heating

3: 57 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; triethylamine; In diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0968-0896(01)00107-9

upstream raw materials:

phenylacetylaminoacetaldehyde

2-hydroxy-2-methylpropanenitrile

phenyl-acetic acid-(2,2-diethoxy-ethylamide)

phenylacetyl chloride

Downstream raw materials:

1-(2-benzoxazolyl)-2-(phenylacetylamino)ethanol

N-(2-benzooxazol-2-yl-2-oxo-ethyl)-2-phenyl-acetamide

Refernces