5,7-dichloro-3-phenylbenzofuran

Base Information

• Chemical Name: 5,7-dichloro-3-phenylbenzofuran
• CAS No.: 54923-52-3
• Molecular Formula: C₁₄H₈Cl₂O
• Molecular Weight: 263.123
• Mol file: 54923-52-3.mol

Synonyms:5,7-dichloro-3-phenylbenzofuran

Chemical Property of 5,7-dichloro-3-phenylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7-dichloro-3-phenylbenzofuran

There total 2 articles about 5,7-dichloro-3-phenylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + (3,5-dichloro-2-hydroxyphenyl)(phenyl)methanone (7396-92-1) → 5,7-dichloro-3-phenylbenzofuran (54923-52-3)

Guidance literature:

With 8-quinolinol; oxygen; copper (I) acetate; potassium carbonate; at 140 ℃; for 24h; under 760.051 Torr;

DOI:10.1002/anie.201108513

Reference yield:

iodobenzene (591-50-4) + 3,5-dichlorosalicyclaldehyde (90-60-8) → 5,7-dichloro-3-phenylbenzofuran (54923-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; lithium chloride; palladium dichloride / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

2: 8-quinolinol; oxygen; copper (I) acetate; potassium carbonate / 24 h / 140 °C / 760.05 Torr

With 8-quinolinol; oxygen; copper (I) acetate; sodium carbonate; potassium carbonate; lithium chloride; palladium dichloride; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201108513

upstream raw materials:

iodobenzene

3,5-dichlorosalicyclaldehyde

N,N-dimethyl acetamide

(3,5-dichloro-2-hydroxyphenyl)(phenyl)methanone

Refernces

• 1、 Moure, Maria J.,Sanmartin, Raul,Dominguez, Esther. "Benzofurans from benzophenones and dimethylacetamide: Copper-promoted cascade formation of furan O1-C2 and C2-C3 bonds under oxidative conditions". . p. 3220 - 3224. Retrieved 2012/05/05.