Technology Process of (3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine
There total 5 articles about (3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine which
guide to synthetic route it.
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synthetic route:
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150085-16-8
(3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine
- Guidance literature:
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With
barium chlorate monohydrate;
osmium(VIII) oxide;
In
water; tert-butyl alcohol;
at 20 ℃;
for 28h;
DOI:10.1016/S0040-4020(01)86312-2
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150085-16-8
(3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1) 4 Angstroem molecular sieves, 2) tetrabutylammonium periodate / 1) dichloromethane, room temperature, 24 h, 2) dichloromethane, -65 deg C to room temperature, 2 h
2: 49 percent / barium chlorate monohydrate / osmium(VIII) oxide / H2O; 2-methyl-propan-2-ol / 28 h / 20 °C
With
barium chlorate monohydrate; 4 A molecular sieve; tetrabutylammonium periodite;
osmium(VIII) oxide;
In
water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)86312-2
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-
150085-16-8
(3S,4S,5S,6S,2'S,4'S,5'R)-2-benzyloxycarbonyl-4,5-dihydroxy-6-(3,4-dimethyl-5-phenyloxazolidin-2-yl)-3-methyl-3,4,5,6-tetrahydro-1,2-oxazine
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 4 Angstroem molecular sieves / CH2Cl2 / 24 h / Ambient temperature
2: 1) 4 Angstroem molecular sieves, 2) tetrabutylammonium periodate / 1) dichloromethane, room temperature, 24 h, 2) dichloromethane, -65 deg C to room temperature, 2 h
3: 49 percent / barium chlorate monohydrate / osmium(VIII) oxide / H2O; 2-methyl-propan-2-ol / 28 h / 20 °C
With
barium chlorate monohydrate; 4 A molecular sieve; tetrabutylammonium periodite;
osmium(VIII) oxide;
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)86312-2