N-(4-chlorophenyl)selenocarbamate of cholestanol

Base Information

• Chemical Name: N-(4-chlorophenyl)selenocarbamate of cholestanol
• CAS No.: 154592-71-9
• Molecular Formula: C₃₄H₅₂ClNOSe
• Molecular Weight: 605.206
• Mol file: 154592-71-9.mol

Synonyms:N-(4-chlorophenyl)selenocarbamate of cholestanol

Chemical Property of N-(4-chlorophenyl)selenocarbamate of cholestanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chlorophenyl)selenocarbamate of cholestanol

There total 4 articles about N-(4-chlorophenyl)selenocarbamate of cholestanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-chlorophenyl isoselenocyanate (14223-48-4) + Cholestanol (80-97-7) → N-(4-chlorophenyl)selenocarbamate of cholestanol (154592-71-9)

Guidance literature:

With potassium hydride; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80783-3

Reference yield:

N-(4-chlorophenyl)formamide (2617-79-0) → N-(4-chlorophenyl)selenocarbamate of cholestanol (154592-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Et₃N, Se(powder), phosgene / toluene / 0 - 110 °C

2: 87 percent / potassium hydride / tetrahydrofuran / 4 h / Ambient temperature

With phosgene; selenium; potassium hydride; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4020(01)80783-3

Reference yield:

4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)selenocarbamate of cholestanol (154592-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / 12 h / Heating

2: 65 percent / Et₃N, Se(powder), phosgene / toluene / 0 - 110 °C

3: 87 percent / potassium hydride / tetrahydrofuran / 4 h / Ambient temperature

With phosgene; selenium; potassium hydride; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4020(01)80783-3

upstream raw materials:

p-chlorophenyl isoselenocyanate

Cholestanol

N-(4-chlorophenyl)formamide

p-chlorophenyl isocyanide

Downstream raw materials:

5α-cholest-3-ene

cholest-2-ene

p-chlorphenylisocyanate

Refernces