octyl-phenyl-phosphinic acid ethyl ester

Base Information

• Chemical Name: octyl-phenyl-phosphinic acid ethyl ester
• CAS No.: 109730-22-5
• Molecular Formula: C₁₆H₂₇O₂P
• Molecular Weight: 282.363
• Mol file: 109730-22-5.mol

Synonyms:octyl-phenyl-phosphinic acid ethyl ester

Chemical Property of octyl-phenyl-phosphinic acid ethyl ester

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of octyl-phenyl-phosphinic acid ethyl ester

There total 11 articles about octyl-phenyl-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bromobenzene (108-86-1,52753-63-6) + octylphosphinic acid ethyl ester → octyl-phenyl-phosphinic acid ethyl ester (109730-22-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; toluene; at 115 ℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1002/adsc.201300069

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + oct-1-ene (111-66-0,25068-25-1) + ethyl phosphinate (14684-32-3) → octyl-phenyl-phosphinic acid ethyl ester (109730-22-5)

Guidance literature:

oct-1-ene; ethyl phosphinate; With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; In toluene; for 24h; Inert atmosphere; Reflux;

bromobenzene; With N-ethyl-N,N-diisopropylamine; In ethylene glycol; toluene; at 115 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201300069

Reference yield: 81.0%

iodobenzene (591-50-4) + octylphosphinic acid ethyl ester → octyl-phenyl-phosphinic acid ethyl ester (109730-22-5)

Guidance literature:

With palladium diacetate; ethylene glycol; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol201222n

upstream raw materials:

oct-1-ene

ethyl Phenylphosphinate

1-Iodooctane

1-bromo-octane

Downstream raw materials:

octyl(phenyl)phosphinic acid

Refernces

• 1、 Ortial, Stephanie,Fisher, Henry C.,Montchamp, Jean-Luc. "Hydrophosphinylation of unactivated terminal alkenes catalyzed by nickel chloride". . p. 6599 - 6608. Retrieved 2013/07/26.
• 2、 Abrunhosa-Thomas, Isabelle,Sellers, Claire E.,Montchamp, Jean-Luc. "Alkylation of H-phosphinate esters under basic conditions". . p. 2851 - 2856. Retrieved 2008/02/01.