N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine

Base Information

• Chemical Name: N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine
• CAS No.: 127073-27-2
• Molecular Formula: C₃₅H₃₀IN₃O₄
• Molecular Weight: 683.545
• Mol file: 127073-27-2.mol

Synonyms:N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine

Chemical Property of N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine

There total 6 articles about N⁴-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N4-benzoyl-2'-deoxy-3'-O-mesyl-5'-O-tritylcytidine (108895-51-8) → N4-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine (127073-27-2)

Guidance literature:

With lithium iodide; In ethyl acetate; for 2.5h; Heating;

DOI:10.1002/jhet.5570260605

Reference yield:

trityl chloride (76-83-5) → N4-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine (127073-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / pyridine / 70 h / Ambient temperature

2: 87 percent / pyridine / 1.5 h / Ambient temperature

3: 63 percent / LiI / ethyl acetate / 2.5 h / Heating

With lithium iodide; In pyridine; ethyl acetate;

DOI:10.1002/jhet.5570260605

Reference yield:

benzoic acid anhydride (93-97-0) → N4-benzoyl-2',3'-dideoxy-3'-iodo-5'-O-tritylcytidine (127073-27-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / ethanol / 2 h / Heating

2: 72 percent / pyridine / 70 h / Ambient temperature

3: 87 percent / pyridine / 1.5 h / Ambient temperature

4: 63 percent / LiI / ethyl acetate / 2.5 h / Heating

With lithium iodide; In pyridine; ethanol; ethyl acetate;

DOI:10.1002/jhet.5570260605

upstream raw materials:

N⁴-benzoyl-2'-deoxy-3'-O-mesyl-5'-O-tritylcytidine

trityl chloride

benzoic acid anhydride

5'-O-dimethoxytrityl-N⁴-benzoyl-2'-deoxycytidine

Downstream raw materials:

N⁴-benzoyl-2',3'-dideoxy-5'-O-tritylcytidine

N⁴-benzoyl-2',3'-dideoxycytidine

Refernces