4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid

Base Information

• Chemical Name: 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid
• CAS No.: 88427-81-0
• Molecular Formula: C₁₄H₁₄N₂O₃
• Molecular Weight: 258.277
• Mol file: 88427-81-0.mol

Synonyms:4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid

Chemical Property of 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid

There total 5 articles about 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanenitrile (88427-89-8) → 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid (88427-81-0)

Guidance literature:

With hydrogenchloride; In propan-1-ol; for 7h; Heating;

DOI:10.1021/jm00148a006

Reference yield:

1-(4-formylphenyl)-1H-imidazole (10040-98-9) → 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid (88427-81-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) p-toluenesulfonic acid / 1.) dioxane, reflux, 0.5 h, 2.) dioxane, H₂O, reflux, 1 h

2: 58.1 g / KOH / tetrahydrofuran; methanol

3: 79 percent / 75percent aq. CH₃COOH / 3 h / Heating

4: 30.9 g / 20percent aq. HCl / propan-1-ol / 7 h / Heating

With hydrogenchloride; potassium hydroxide; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; propan-1-ol;

DOI:10.1021/jm00148a006

Reference yield:

α-<4-(1H-imidazol-1-yl)phenyl>-4-morpholineacetonitrile (86798-58-5) → 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid (88427-81-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 58.1 g / KOH / tetrahydrofuran; methanol

2: 79 percent / 75percent aq. CH₃COOH / 3 h / Heating

3: 30.9 g / 20percent aq. HCl / propan-1-ol / 7 h / Heating

With hydrogenchloride; potassium hydroxide; acetic acid; In tetrahydrofuran; methanol; propan-1-ol;

DOI:10.1021/jm00148a006

upstream raw materials:

crotononitrile

α-<4-(1H-imidazol-1-yl)phenyl>-4-morpholineacetonitrile

4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanenitrile

1-(4-formylphenyl)-1H-imidazole

Downstream raw materials:

6-<4-(1H-imidazol-1-yl)phenyl>-5-methyl-3(2H)-pyridazinone

4-(4-fluorophenyl)-4-oxopropionic acid

4-(1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

imazodan

Refernces

• 1、 Sircar, Ila,Duell, Bradley L.,Bobowski, George,Bristol, James A.,Evans, Dale B.. "Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents". . p. 1405 - 1413. Retrieved 2007/10/02.