pteroyl-lys-HYNIC

Base Information

• Chemical Name: pteroyl-lys-HYNIC
• CAS No.: 1296133-92-0
• Molecular Formula: C₃₅H₃₈N₁₂O₅
• Molecular Weight: 706.764
• Mol file: 1296133-92-0.mol

Synonyms:pteroyl-lys-HYNIC

Chemical Property of pteroyl-lys-HYNIC

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pteroyl-lys-HYNIC

There total 8 articles about pteroyl-lys-HYNIC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

succinimidyl 6-[2-(4-dimethylamino)benzaldehydrazono]nicotinate (186305-06-6) + pteroyl-lys (55668-03-6) → pteroyl-lys-HYNIC (1296133-92-0)

Guidance literature:

With pyridine; In dimethyl sulfoxide; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.02.014

Reference yield:

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid (2418-95-3) → pteroyl-lys-HYNIC (1296133-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 7 h / 20 °C

2: pyridine; trifluoroacetic acid / N,N-dimethyl-formamide / 0 °C

3: pyridine / dimethyl sulfoxide / 16 h / 20 °C

With pyridine; trifluoroacetic acid; N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.014

Reference yield:

folate (59-30-3) → pteroyl-lys-HYNIC (1296133-92-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 10 h / 0 - 20 °C

2.1: tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3.1: hydrazine / dimethyl sulfoxide / 12 h / 20 °C

4.1: potassium thioacyanate; trifluoroacetic acid / -10 - 0 °C

4.2: 5 h / 20 °C

5.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 7 h / 20 °C

6.1: pyridine; trifluoroacetic acid / N,N-dimethyl-formamide / 0 °C

7.1: pyridine / dimethyl sulfoxide / 16 h / 20 °C

With pyridine; potassium thioacyanate; trifluoroacetic acid; hydrazine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.014

upstream raw materials:

C₂₅H₃₂N₈O₆

succinimidyl 6-[2-(4-dimethylamino)benzaldehydrazono]nicotinate

pteroyl-lys

C₁₄H₁₃N₇O₂

Refernces