4-(hydroxymethyl)benzyl pivalate

Base Information

• Chemical Name: 4-(hydroxymethyl)benzyl pivalate
• CAS No.: 1185742-86-2
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 1185742-86-2.mol

Synonyms:4-(hydroxymethyl)benzyl pivalate

Chemical Property of 4-(hydroxymethyl)benzyl pivalate

Chemical Property:

Purity/Quality:

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Technology Process of 4-(hydroxymethyl)benzyl pivalate

There total 1 articles about 4-(hydroxymethyl)benzyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-O-acetoxymethylpivaloyloxymethylbenzene → 4-(hydroxymethyl)benzyl pivalate (1185742-86-2)

Guidance literature:

With methanol; oxo[hexa(trifluoroacetato)]tetrazinc; for 12h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201000960

Reference yield: 93.0%

4-(hydroxymethyl)benzyl pivalate (1185742-86-2) → 4-formylbenzyl pivalate (1393662-17-3)

Guidance literature:

4-(hydroxymethyl)benzyl pivalate; With oxalyl dichloride; 3-methyl-1-[6-(methanesulfinyl)hexan-1-yl]-1H-imidazolium p-toluenesulfonate; In dichloromethane; at -70 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -70 - 20 ℃; for 5.5h;

DOI:10.1016/j.tet.2012.06.026

Reference yield: 89.0%

4-(hydroxymethyl)benzyl pivalate (1185742-86-2) + ethyl acetate (141-78-6) → 4-O-acetoxymethylpivaloyloxymethylbenzene

Guidance literature:

With C₁₂F₁₈O₁₃Zn₄; for 36h; Reflux; Inert atmosphere;

DOI:10.1055/s-0029-1217335

Downstream raw materials:

4-formylbenzyl pivalate

Refernces