diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate

Base Information

• Chemical Name: diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate
• CAS No.: 1415961-22-6
• Molecular Formula: C₂₅H₃₉O₄P
• Molecular Weight: 434.556
• Mol file: 1415961-22-6.mol

Synonyms:diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate

Chemical Property of diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate

There total 8 articles about diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl chlorophosphate (814-49-3) + 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentylphenol → diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate (1415961-22-6)

Guidance literature:

2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentylphenol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

diethyl chlorophosphate; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.10.080

Reference yield:

3-pentyl phenol (20056-66-0) → diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate (1415961-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium sulfate; boron trifluoride diethyl etherate / dichloromethane / 1.5 h / -78 - -10 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium hydride; magnesium sulfate; In tetrahydrofuran; dichloromethane; mineral oil; 1.1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.tetlet.2012.10.080

Reference yield:

(1S,2S,5R)-2-hydroxy-N,N,2-trimethyl-5-(prop-1-en-2-yl)cyclohexanamineoxide (1415961-21-5) → diethyl 2-[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-5-pentylphenyl phosphate (1415961-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 180 °C / 1 Torr / Pyrolysis

2.1: magnesium sulfate; boron trifluoride diethyl etherate / dichloromethane / 1.5 h / -78 - -10 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium hydride; magnesium sulfate; In tetrahydrofuran; dichloromethane; mineral oil; 1.1: |Cope Elimination / 2.1: |Friedel-Crafts Alkylation;

DOI:10.1016/j.tetlet.2012.10.080

upstream raw materials:

3-methyl-phenol

D-limonene

3-pentyl phenol

diethyl chlorophosphate

Downstream raw materials:

[(1R,6R)-3-methyl-6-(1-prop-1-en-2-yl)-cyclohex-2-enyl]-4-pentylbenzene

Refernces