(2-Chloro-4,5-difluorophenyl)methanol

Base Information

• Chemical Name: (2-Chloro-4,5-difluorophenyl)methanol
• CAS No.: 288154-93-8
• Molecular Formula: C7H5 Cl F2 O
• Molecular Weight: 178.566
• Hs Code.: 2906299090
• European Community (EC) Number: 657-323-0
• Mol file: 288154-93-8.mol

Synonyms:(2-chloro-4,5-difluorophenyl)methanol;288154-93-8;2-Chloro-4,5-difluorobenzyl alcohol;SCHEMBL3824032;2,4-DIAMINOANISOLESULFATE;VPBQEWYEJDAYKP-UHFFFAOYSA-N;MFCD02063025;2-Chloro-4,5-difluorobenzenemethanol;AKOS006276277;JS-4416;SB84568;(2-chloro-4,5-difluoro-phenyl)-methanol;CS-0194226;E89620;J-508710

Chemical Property of (2-Chloro-4,5-difluorophenyl)methanol

Chemical Property:

• Vapor Pressure: 0.093mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 214.2°Cat760mmHg
• PKA: 13.20±0.10(Predicted)
• Flash Point: 83.3°C
• PSA: 20.23000
• Density: 1.444g/cm³
• LogP: 2.11050
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.9996988
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

98.5% ^*data from raw suppliers

2-Chloro-4,5-difluorobenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1F)F)Cl)CO

Technology Process of (2-Chloro-4,5-difluorophenyl)methanol

There total 1 articles about (2-Chloro-4,5-difluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4,5-difluorobenzoic acid (110877-64-0) → (2-chloro-5-fluoro-4-methoxyphenyl)methanol (288154-93-8)

Guidance literature:

2-chloro-4,5-difluorobenzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 4.33h;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃;

Reference yield: 71.6%

(2-chloro-5-fluoro-4-methoxyphenyl)methanol (288154-93-8) → 2-chloro-4,5-difluorobenzaldehyde (165047-23-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

(2-chloro-5-fluoro-4-methoxyphenyl)methanol (288154-93-8) → 1-bromomethyl-2-chloro-5-fluoro-4-methoxybenzene (874285-21-9)

Guidance literature:

With hydrogen bromide; In water; at 8 - 50 ℃; for 1.16667h;

upstream raw materials:

2-chloro-4,5-difluorobenzoic acid

Downstream raw materials:

1-bromomethyl-2-chloro-5-fluoro-4-methoxybenzene

2-chloro-4,5-difluorobenzaldehyde

Refernces