1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
• CAS No.: 288148-34-5
• Molecular Formula: C4H5 Cl N2 O2 S
• Molecular Weight: 180.615
• Hs Code.: 2933199090
• Mol file: 288148-34-5.mol

Synonyms:1-Methyl-1H-pyrazole-4-sulfonylchloride

Chemical Property of 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 364.206°C at 760 mmHg
• PKA: -3.33±0.10(Predicted)
• Flash Point: 174.066°C
• PSA: 60.34000
• Density: 1.706g/cm³
• LogP: 1.42840
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-1H-pyrazole-4-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-1H-pyrazole-4-sulfonyl Chloride is used as a reagent in the preparation of benzoindazoles as glucocorticoid receptor modulators.

Technology Process of 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)

There total 2 articles about 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-iodo-1-methyl-1H-pyrazole (39806-90-1) → 1-methyl-1H-pyrazole-4-sulfonyl chloride (288148-34-5)

Guidance literature:

4-iodo-1-methyl-1H-pyrazole; With n-butyllithium; In diethyl ether; for 1h; cooling;

With sulfur dioxide; In diethyl ether; at 20 ℃; for 1h;

With N-chloro-succinimide; In dichloromethane; for 3h;

DOI:10.1016/j.bmc.2006.05.076

Reference yield: 33.0%

1-methyl-1H-pyrazole (930-36-9) → 1-methyl-1H-pyrazole-4-sulfonyl chloride (288148-34-5)

Guidance literature:

With chlorosulfonic acid; at 0 - 110 ℃; for 3h;

Reference yield: 100.0%

methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate (907587-49-9) + 1-methyl-1H-pyrazole-4-sulfonyl chloride (288148-34-5) → methyl 4-{[2-{[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate (909897-12-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2006.05.076

upstream raw materials:

4-iodo-1-methyl-1H-pyrazole

1-methyl-1H-pyrazole

Downstream raw materials:

methyl 4-{[2-{[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine

ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-pyrazole-4-sulfonamide

Refernces

• 1、 Naganawa, Atsushi,Matsui, Toshiaki,Saito, Tetsuji,Ima, Masaki,Tatsumi, Tadashi,Yamamoto, Shingo,Murota, Masayuki,Yamamoto, Hiroshi,Maruyama, Takayuki,Ohuchida, Shuichi,Nakai, Hisao,Kondo, Kigen,Toda, Masaaki. "Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists". . p. 6628 - 6639. Retrieved 2007/10/03.
• 2、 -. "Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia". . . Retrieved 2008/06/13.