2-(Tritylthio)ethanamine

Base Information

• Chemical Name: 2-(Tritylthio)ethanamine
• CAS No.: 1095-85-8
• Molecular Formula: C21H21 N S
• Molecular Weight: 319.47
• NSC Number: 96704
• DSSTox Substance ID: DTXSID10911219
• Nikkaji Number: J1.121.193C
• Pharos Ligand ID: 9HBRYKGLLPA4
• ChEMBL ID: CHEMBL408072
• Mol file: 1095-85-8.mol

Synonyms:2-(tritylthio)ethanamine;1095-85-8;2-tritylsulfanylethanamine;2-(tritylsulfanyl)ethanamine;S-tritylcysteamine;2-[(triphenylmethyl)sulfanyl]ethan-1-amine;2-(Tritylthio)ethanamine,2-[(triphenylmethyl)thio]- Ethanamine;2-Tritylsulfanyl-ethylamine;NSC96704;S-Trityl cysteamine;S-Trityl-cysteamine;(S-Trityl)Cysteamine;2-tritylthioethylamine;(tritylsulfanyl)ethylamine;2-tritylsulfanylethylamine;2-(Tritylthio)ethaneamine;H2N-CH2-CH2-STrt;2-(tritylsulfanyl)ethylamine;SCHEMBL38315;CHEMBL408072;BDBM23802;DTXSID10911219;2-(tritylsulfanyl)-1-ethaneamine;XZOWICPSVWHCTC-UHFFFAOYSA-N;BAA09585;2-[(Triphenylmethyl)thio]ethylamine;S-triphenylmethyl-2-aminoethanethiol;MFCD00822629;NSC-96704;2-(triphenylmethylmercapto)-ethylamine;AKOS030214491;S-(triphenylmethyl) 2-aminoethanethiol;Ethanamine, 2-[(triphenylmethyl)thio]-;Triphenylmethyl-containing compound, 31;AS-63757;CS-0156531;D80342

Chemical Property of 2-(Tritylthio)ethanamine

Chemical Property:

• Vapor Pressure: 3.73E-08mmHg at 25°C
• Boiling Point: 446.1°Cat760mmHg
• Flash Point: 223.6°C
• Density: 1.127g/cm³
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 319.13947085
• Heavy Atom Count: 23
• Complexity: 279

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCCN

Technology Process of 2-(Tritylthio)ethanamine

There total 16 articles about 2-(Tritylthio)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triphenylmethyl alcohol (76-84-6) + 2-mercaptoethylamine hydrochloride (156-57-0) → 2-amino tritylthio ethane (1095-85-8)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 3h;

Reference yield: 98.0%

2-mercaptoethylamine hydrochloride (156-57-0) → 2-amino tritylthio ethane (1095-85-8)

Guidance literature:

With choline chloride; urea; In trifluoroacetic acid; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2020.131898

Reference yield: 96.26%

2-mercaptoethylamine hydrochloride (156-57-0) + trityl chloride (76-83-5) → 2-amino tritylthio ethane (1095-85-8)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 3h;

DOI:10.1002/cmdc.202100548

upstream raw materials:

triphenylmethanethiol

2-bromoethylamine hydrobromide

2-mercaptoethylamine hydrochloride

trityl chloride

Downstream raw materials:

3-<2-Tritylmercapto-aethylamino>-propionsaeure-amid

{2-[(2-tert-Butoxycarbonylamino-ethyl)-(2-tritylsulfanyl-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester

[2-(1-benzyl-1H-imidazol-4-yl)-1-(2-tritylsulfanyl-ethylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

N-phenyl-N'-(2-tritylsulfanyl-ethyl)-malonamide

Refernces

• 1、 Chang, Wen-Yi,Kao, Hao-Wen,Wang, Hsin-Ell,Chen, Jenn-Tzong,Lin, Wuu-Jyh,Wang, Shyh-Jen,Chen, Chuan-Lin. "Synthesis and biological evaluation of technetium-99m labeled galactose derivatives as potential asialoglycoprotein receptor probes in a hepatic fibrosis mouse model". . p. 6486 - 6491. Retrieved 2013.
• 2、 Yang, Qinglai,Bai, Ling,Zhang, Yuanqing,Zhu, Fangxia,Xu, Yuhong,Shao, Zhifeng,Shen, Yu-Mei,Gong, Bing. "Dynamic covalent diblock copolymers: Instructed coupling, micellation and redox responsiveness". . p. 7431 - 7441. Retrieved 2014.
• 3、 Yu, Xiaoling,Zhang, Bingbing,Shan, Guangsheng,Wu, Yue,Yang, Feng-Ling,Lei, Xinsheng. "Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A". . p. 549 - 555. Retrieved 2018.
• 4、 Baumann, Sascha,Schoof, Sebastian,Bolten, Marcel,Haering, Claudia,Takagi, Motoki,Shin-Ya, Kazuo,Arndt, Hans-Dieter. "Molecular determinants of microbial resistance to thiopeptide antibiotics". . p. 6973 - 6981. Retrieved 2010.
• 5、 Naumiec, Gregory R.,Lincourt, Grace,Clever, Jeremy P.,McGregor, Michael A.,Kovoor, Abraham,Deboef, Brenton. "Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter". . p. 2537 - 2540. Retrieved 2015.
• 6、 Cheng, Chien-Chung,Lu, Yen-Lin. "Cleavage of the Pt-S bond of thiolated terpyridine-platinum(II) complexes by copper(II) and zinc(II) ions in phosphate buffer". . p. 253 - 254. Retrieved 1998.
• 7、 Qu, Yun,Wang, Xinxin,Pei, Zhichao,Pei, Yuxin. "Cancer-Mitochondria Dual-Targeting Glycol/Ferrocenium-Based Polydopamine Nanoparticles for Synergistic Photothermal and Photodynamic Therapy". supporting information. . Retrieved 2021/11/23.
• 8、 Quivelli, Andrea F.,D'Addato, Giovanna,Vitale, Paola,García-álvarez, Joaquín,Perna, Filippo M.,Capriati, Vito. "Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water". . . Retrieved 2021/01/18.