4-Methoxybenzophenone oxime

Base Information

• Chemical Name: 4-Methoxybenzophenone oxime
• CAS No.: 24316-60-7
• Molecular Formula: C14H13 N O2
• Molecular Weight: 227.263
• Nikkaji Number: J786.673I
• Mol file: 24316-60-7.mol

Synonyms:4-methoxybenzophenone oxime;Benzophenone,4-methoxy-, oxime;METHANONE,(4-METHOXYPHENYL)PHENYL-, OXIME;24316-60-7;4-Methoxybenzophenone oxime\r\n

Chemical Property of 4-Methoxybenzophenone oxime

Chemical Property:

• Vapor Pressure: 2.65E-06mmHg at 25°C
• Boiling Point: 375.4°Cat760mmHg
• Flash Point: 180.9°C
• Density: 1.08g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=NO)C2=CC=CC=C2
• Isomeric SMILES: COC1=CC=C(C=C1)/C(=N\O)/C2=CC=CC=C2

Technology Process of 4-Methoxybenzophenone oxime

There total 7 articles about 4-Methoxybenzophenone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methoxybenzophenone phenylhydrazone (75600-86-1) → (4-methoxyphenyl)(phenyl)methanone oxime (24316-60-7)

Guidance literature:

With deuterium; In dichloromethane; at -78 - 25 ℃; for 16h;

DOI:10.1002/chem.202001590

Reference yield: 74.0%

4-Methoxybenzophenone (611-94-9) → (4-methoxyphenyl)(phenyl)methanone oxime (24316-60-7)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; at 100 ℃; for 4h; Sealed tube;

DOI:10.1016/j.tetlet.2016.11.054

Reference yield: 39.0%

4-methoxyphenylboronic acid (5720-07-0) + benzohydroximoyl chloride (698-16-8) → (4-methoxyphenyl)(phenyl)methanone oxime (24316-60-7)

Guidance literature:

With potassium phosphate; In dichloromethane; at 60 ℃; for 4.5h; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201906057

upstream raw materials:

4-Methoxybenzophenone

Benzaldoxime

benzaldehyde

4-methoxyphenylboronic acid

Downstream raw materials:

4-Methoxybenzophenone

benzyl(4-methoxyphenyl)amine

5-(4-methoxyphenyl)-1-phenyl-1H- tetrazole

1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole

Refernces

• 1、 Shibasaki, Kaho,Togo, Hideo. "Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide". . p. 1816 - 1830. Retrieved 2020/11/19.
• 2、 Zhi, Peng,Xi, Zi-Wei,Wang, Dan-Yan,Wang, Wei,Liang, Xue-Zheng,Tao, Fei-Fei,Shen, Run-Pu,Shen, Yong-Miao. "Vilsmeier-Haack reagent mediated synthetic transformations with an immobilized iridium complex photoredox catalyst". supporting information. p. 709 - 717. Retrieved 2019/01/10.