Technology Process of 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde
There total 10 articles about 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
pyrrole-3-carboxaldehyde;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / ethanol / 48 h / 75 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C
3.1: dmap / dichloromethane / 1 h / 20 °C
3.2: 2.5 h / 150 °C
4.1: hydrogenchloride / ethanol / 1 h / 120 °C
5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C
5.2: 3 h / -20 - 0 °C
6.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C
6.2: 1 h / 0 °C
With
hydrogenchloride; dmap; hydrogen; sodium hydride; acetic acid; triethylamine; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diethylamino-sulfur trifluoride / tetrahydrofuran / 5 h / 50 °C
2.1: hydrogenchloride; acetic acid / 2 h / 20 °C
3.1: triethylamine / ethanol / 48 h / 75 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C
5.1: dmap / dichloromethane / 1 h / 20 °C
5.2: 2.5 h / 150 °C
6.1: hydrogenchloride / ethanol / 1 h / 120 °C
7.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C
7.2: 3 h / -20 - 0 °C
8.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C
8.2: 1 h / 0 °C
With
hydrogenchloride; dmap; diethylamino-sulfur trifluoride; hydrogen; sodium hydride; acetic acid; triethylamine; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;