2-<<(isopropylidene)amino>oxy>benzonitrile

Base Information

• Chemical Name: 2-<<(isopropylidene)amino>oxy>benzonitrile
• CAS No.: 126940-09-8
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.202
• Mol file: 126940-09-8.mol

Synonyms:2-<<(isopropylidene)amino>oxy>benzonitrile

Chemical Property of 2-<<(isopropylidene)amino>oxy>benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<<(isopropylidene)amino>oxy>benzonitrile

There total 2 articles about 2-<<(isopropylidene)amino>oxy>benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-fluorobenzonitrile (394-47-8) + acetone oxime (127-06-0) → 2-<<(isopropylidene)amino>oxy>benzonitrile (126940-09-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 1h;

Reference yield:

2-fluorobenzonitrile (394-47-8) → 2-<<(isopropylidene)amino>oxy>benzonitrile (126940-09-8)

Guidance literature:

Reference yield:

2-<<(isopropylidene)amino>oxy>benzonitrile (126940-09-8) → C24H19N3O5 (1262725-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 3 h / 80 °C

2.1: formic acid / palladium 10% on activated carbon / ethanol / 5 h / Inert atmosphere; Reflux

2.2: 3 h / 25 - 70 °C

3.1: sodium methylate / methanol / 3 h / 60 °C

3.2: 20 °C

With hydrogenchloride; formic acid; sodium methylate; palladium 10% on activated carbon; In methanol; ethanol; water;

upstream raw materials:

2-fluorobenzonitrile

acetone oxime

Downstream raw materials:

C₂₃H₁₇N₃O₄

C₂₂H₁₄N₄O₂

C₂₄H₁₉N₃O₅

C₂₂H₁₄F₃N₃O₂

Refernces

• 1、 -. "BICYCLIC PYRIMIDINONES AND USES THEREOF". Page/Page column 120-121. . Retrieved 2008/12/06.
• 2、 Shutske, Gregory M.,Kapples, Kevin J.. "A Novel Synthesis of 3-Amino-1,2-benzisoxazoles - an Entry into the Isoxazolobenzoxazepine Ring System". . p. 1293 - 1298. Retrieved 2007/10/02.