neratinib maleate monohydrate

Base Information

• Chemical Name: neratinib maleate monohydrate
• CAS No.: 1144516-12-0
• Molecular Formula: C₄H₄O₄*C₃₀H₂₉ClN₆O₃*H₂O
• Molecular Weight: 691.14
• Mol file: 1144516-12-0.mol

Synonyms:neratinib maleate monohydrate

Chemical Property of neratinib maleate monohydrate

Chemical Property:

Purity/Quality:

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Technology Process of neratinib maleate monohydrate

There total 1 articles about neratinib maleate monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic acid (110-16-7,26099-09-2) + neratinib (698387-09-6) → neratinib maleate monohydrate (1144516-12-0)

Guidance literature:

With water; In propan-1-ol; at 25 - 60 ℃; Product distribution / selectivity;

Reference yield: 84.0%

neratinib maleate monohydrate (1144516-12-0) → (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide maleate

Guidance literature:

at 25 - 50 ℃; for 24h; under 10 Torr;

upstream raw materials:

maleic acid

neratinib

Refernces