Technology Process of ratanhine
There total 17 articles about ratanhine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; methanol;
at 65 ℃;
for 1h;
DOI:10.1021/ja0716204
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 79 percent / DCC; DMAP / CH2Cl2 / 21 h / 23 °C
2: 59 percent / Br2 / CH2Cl2 / 0.17 h / 0 °C
3: 97 percent / DBU / acetonitrile / 0.42 h / 23 °C
4: 70 percent / K3PO4 / PdCl2(dppf) / tetrahydrofuran / 15 h / 65 °C
5: 81 percent / K2CO3 / 2-(dicyclohexylphosphino)biphenyl; Pd2dba3 / tetrahydrofuran / 20 h / 65 °C
6: aq. HCl / methanol; tetrahydrofuran / 1 h / 65 °C
With
hydrogenchloride; dmap; potassium phosphate; bromine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
5: Suzuki-Miyaura coupling;
DOI:10.1021/ja0716204
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 365 mg / dimethylsulfoxide; benzene / 11 h / Heating
2: 73 percent / K2CO3 / 2-(dicyclohexylphosphino)biphenyl; Pd2dba3 / tetrahydrofuran / 28 h / 80 °C
3: 99 percent / aq. NaOH / tetrahydrofuran / 0.17 h / 25 °C
4: 81 percent / K2CO3 / 2-(dicyclohexylphosphino)biphenyl; Pd2dba3 / tetrahydrofuran / 20 h / 65 °C
5: aq. HCl / methanol; tetrahydrofuran / 1 h / 65 °C
With
hydrogenchloride; sodium hydroxide; potassium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); CyJohnPhos;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; benzene;
2: Suzuki-Miyaura coupling / 4: Suzuki-Miyaura coupling;
DOI:10.1021/ja0716204