N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide

Base Information

• Chemical Name: N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide
• CAS No.: 1186514-46-4
• Molecular Formula: C₂₈H₃₀N₄O₂
• Molecular Weight: 454.572
• Mol file: 1186514-46-4.mol

Synonyms:N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide

Chemical Property of N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide

There total 9 articles about N₃-(imidazo[1,2-a]pyridin-7-ylmethyl)-N₅-isobutyl-N₅,4'-dimethylbiphenyl-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imidazo[1,2-a]pyridin-7-ylmethanamine (1073428-81-5) + 5-(isobutyl(methyl)carbamoyl)-4'-methylbiphenyl-3-carboxylic acid (1186518-81-9) → N3-(imidazo[1,2-a]pyridin-7-ylmethyl)-N5-isobutyl-N5,4'-dimethylbiphenyl-3,5-dicarboxamide (1186514-46-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

7-(azidomethyl)imidazo[1,2-a]pyridine (1186518-67-1) → N3-(imidazo[1,2-a]pyridin-7-ylmethyl)-N5-isobutyl-N5,4'-dimethylbiphenyl-3,5-dicarboxamide (1186514-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.67 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

Reference yield:

dimethyl 5-bromoisophthalate (51760-21-5) → N3-(imidazo[1,2-a]pyridin-7-ylmethyl)-N5-isobutyl-N5,4'-dimethylbiphenyl-3,5-dicarboxamide (1186514-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / Reflux

2.1: lithium hydroxide / 1,4-dioxane / 20 °C

2.2: pH 2 - 3

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.1: water; lithium hydroxide / ethanol / 5 h / 20 °C

4.2: pH 3

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

upstream raw materials:

imidazo[1,2-a]pyridin-7-ylmethanamine

5-(isobutyl(methyl)carbamoyl)-4'-methylbiphenyl-3-carboxylic acid

7-(azidomethyl)imidazo[1,2-a]pyridine

5-(ethoxycarbonyl)-4'-methylbiphenyl-3-carboxylic acid

Refernces