1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane

Base Information

• Chemical Name: 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane
• CAS No.: 73200-11-0
• Molecular Formula: C₁₄H₁₇NO₂S
• Molecular Weight: 263.36
• Mol file: 73200-11-0.mol

Synonyms:1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane

Chemical Property of 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane

There total 2 articles about 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2-Acetoxy-2-phenylacetyl)azacyclopentane (73200-21-2) → 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane (73200-11-0)

Guidance literature:

With diphosphorus pentasulfide; In pyridine; for 2.5h; Heating;

DOI:10.1021/jo01298a022

Reference yield:

2-acetoxy-2-phenylacetyl chloride (1638-63-7) → 1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane (73200-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / CH₂Cl₂ / 1.) addition over 30 min, ice-bath cooled, 2.) room temperature, 30 min

2: 87 percent / phosphorus pentasulfide / pyridine / 2.5 h / Heating

With diphosphorus pentasulfide; In pyridine; dichloromethane;

DOI:10.1021/jo01298a022

Reference yield: 93.0%

1-(2-Acetoxy-2-phenylethanethioyl)azacyclopentane (73200-11-0) → 2-hydroxy-2-phenyl-1-(pyrrolidin-1-yl)ethanethione (73200-10-9)

Guidance literature:

With lithium hydroxide; water; In methanol;

DOI:10.1021/jo01298a022

upstream raw materials:

1-(2-Acetoxy-2-phenylacetyl)azacyclopentane

2-acetoxy-2-phenylacetyl chloride

Downstream raw materials:

2-hydroxy-2-phenyl-1-(pyrrolidin-1-yl)ethanethione

4-(1-Azacyclopentyl)-5-phenyloxacyclopent-3-en-2-one

4-(1-Azacyclopentyl)-3-methyl-5-phenyloxacyclopent-3-en-2-one

Refernces