(1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride

Base Information

• Chemical Name: (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride
• CAS No.: 625098-83-1
• Molecular Formula: C₁₃H₁₅NO₂*ClH
• Molecular Weight: 253.729
• Mol file: 625098-83-1.mol

Synonyms:(1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride

Chemical Property of (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride

There total 4 articles about (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + (1R,4S)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylic acid (151907-80-1,108999-93-5) → (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride (625098-83-1)

Guidance literature:

benzyl bromide; (1R,4S)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylic acid; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃;

With water; In DMF (N,N-dimethyl-formamide);

With hydrogenchloride; In 1,3-dioxane;

Reference yield:

C18H23NO4 (862120-91-0) → (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride (625098-83-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

(1R,4S)-4-aminocyclopenten-2-ene-1-carboxylic acid (134003-04-6) → (1S,4R)-1-amino-4-benzyloxycarbonyl-cyclopent-2-ene hydrochloride (625098-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0.5 h

1.2: 168 h

1.3: pH 3

2.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 0.33 h

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); water;

upstream raw materials:

benzyl bromide

(1R,4S)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylic acid

C₁₈H₂₃NO₄

(1R,4S)-4-aminocyclopenten-2-ene-1-carboxylic acid

Downstream raw materials:

C₂₃H₂₈F₃NO₄

C₁₉H₂₅NO₃

Refernces

• 1、 -. "TETRAHYDROPYRANYL CYCLOPENTYL 1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY". Page/Page column 34. . Retrieved 2010/02/14.
• 2、 -. "TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY". Page/Page column 59-60. . Retrieved 2010/02/07.