p-Methoxyamphetamine hydrochloride

Base Information

• Chemical Name: p-Methoxyamphetamine hydrochloride
• CAS No.: 3706-26-1
• Deprecated CAS: 52740-56-4
• Molecular Formula: C10H15 N O . Cl H
• Molecular Weight: 201.696
• Hs Code.: 2922299090
• European Community (EC) Number: 637-072-3,690-788-8
• UNII: 5P66783GRV
• DSSTox Substance ID: DTXSID10958225
• Wikidata: Q27262678
• ChEMBL ID: CHEMBL536709
• Mol file: 3706-26-1.mol

Synonyms:4-methoxyamphetamine;4-methoxyamphetamine hydrochloride;4-methoxyamphetamine hydrochloride, (+-)-isomer;4-methoxyamphetamine hydrochloride, (R)-isomer;4-methoxyamphetamine hydrochloride, (S)-isomer;4-methoxyamphetamine sulfate;4-methoxyamphetamine, (+-)-isomer;4-methoxyamphetamine, (R)-isomer;4-methoxyamphetamine, (S)-isomer;p-methoxy-alpha-methylphenethylamine;p-methoxyamphetamine;para-methoxyamphetamine;paramethoxyamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of p-Methoxyamphetamine hydrochloride

Chemical Property:

• Melting Point: 210-211 °C
• Boiling Point: 258.2°Cat760mmHg
• Flash Point: 107.5°C
• PSA: 35.25000
• Density: 0.99g/cm³
• LogP: 3.08720
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)OC)N.Cl
• Description: 4-Methoxyamphetamine (4-MA), is a serotonergic drug of the amphetamine class. 4-MA exhibits both structural and pharmacological similarity to 3,4-methylenedioxymethamphetamine and may be a more potent hallucinogen, particularly through its effects on serotonergic transmission and through reversible inhibition of the enzyme MAO-A. This product is intended for research and forensic applications.

Technology Process of p-Methoxyamphetamine hydrochloride

There total 3 articles about p-Methoxyamphetamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → 1-methyl-2-(p-methoxyphenyl)-ethylamine hydrochloride (3706-26-1,50505-81-2,52740-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI / tetrahydrofuran / -30 - 0 °C

2: HCl; H₂O / 1 h / Heating

With hydrogenchloride; copper(l) iodide; water; In tetrahydrofuran; 1: Ring cleavage / 2: Hydrolysis;

DOI:10.1016/S0040-4020(97)00188-9

Reference yield:

[2-(4-methoxy-phenyl)-1-methyl-ethyl]-phosphoramidic acid diethyl ester → 1-methyl-2-(p-methoxyphenyl)-ethylamine hydrochloride (3706-26-1,50505-81-2,52740-56-4)

Guidance literature:

With hydrogenchloride; water; for 1h; Heating;

DOI:10.1016/S0040-4020(97)00188-9

Reference yield:

Nitroethane (79-24-3) + 4-methoxy-benzaldehyde (123-11-5) → 1-methyl-2-(p-methoxyphenyl)-ethylamine hydrochloride (3706-26-1,50505-81-2,52740-56-4)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1111/j.2042-7158.1980.tb12909.x

upstream raw materials:

Nitroethane

4-methoxy-benzaldehyde

4-methoxyphenyl magnesium bromide

Downstream raw materials:

1-(4-hydroxyphenyl)propan-2-ammonium chloride

Refernces

• 1、 Green,El Hait. "p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro and in vivo". . p. 262 - 266. Retrieved 2007/10/02.