4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOHYDRAZIDE

Base Information

• Chemical Name: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOHYDRAZIDE
• CAS No.: 276694-16-7
• Molecular Formula: C13H19 B N2 O3
• Molecular Weight: 262.116
• Hs Code.: 2934999090
• Mol file: 276694-16-7.mol

Synonyms:4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzohydrazide

Chemical Property of 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOHYDRAZIDE

Chemical Property:

• PSA: 73.58000
• LogP: 1.68050
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Hydrazinecarbonyl)phenylboronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Hydrazinocarbonyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.

Technology Process of 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOHYDRAZIDE

There total 3 articles about 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (195062-62-5) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzohydrazide (276694-16-7)

Guidance literature:

With hydrazine hydrate; for 24h; Reflux;

DOI:10.1039/d0dt02177f

Reference yield:

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (171364-80-0) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzohydrazide (276694-16-7)

Guidance literature:

With hydrazine hydrate; In methanol;

Reference yield:

4-carboxyphenylboronic acid pinacol ester (180516-87-4) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzohydrazide (276694-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / Reflux

2: hydrazine hydrate / 24 h / Reflux

With sulfuric acid; hydrazine hydrate;

DOI:10.1039/d0dt02177f

upstream raw materials:

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

4-carboxyphenylboronic acid pinacol ester

ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Refernces

• 1、 -. "Process for the preparation of paraoxadiazolyphenylboronic acids". . . Retrieved 2008/06/13.